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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes

Fig. 4

Loss of miR-181b induces tissue factor and VCAM1 expression in vivo. Aortas and spleen of miR-181−/− mice were analyzed with respect to mRNA and protein expression. miR-181b (a), asTF mRNA (b), flTF mRNA (c), murine (mu) TF protein (d) and immunofluorescence (IF) images using an anti-mouse (mu) TF antibody (red), DAPI (blue), and a F-actin probe (green) (e upper panel) in aortic segments. KPNA4 mRNA (f), VCAM1 mRNA (g), VCAM1 protein (h), and IF images using a mouse VCAM1-specific antibody (red) (e lower panel) in aortic tissue. Expression of asTF mRNA (i), flTF mRNA (j), PTEN mRNA (k), muTF protein (l), and IF for muTF (red)(M) in spleen of wt and miR-181−/− animals. n = 4–6 animals per group, compared by Mann–Whitney or student’s t-test

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