Fig. 1

Plasma miR-181b correlates with reduced tissue factor activity and inflammation in diabetes. Plasma of patients with diabetes was analyzed with respect to miR-181b expression. Circulating miR-181b negatively correlated with TF protein (a) as well as TF activity (FXa generation) (b). Moreover, miR-181b expression was related to lower levels of the pro-inflammatory fibrinogen (c) and lower leukocyte counts (d). We also observed a correlation of miR-181b with the TF-specific miR-126 (e) and miR-19a (f). n = 46. Upon normality testing a Spearman or Pearson correlation was performed, r-values and p-values are indicated