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Table 1 Baseline characteristics after propensity score matching

From: Favorable pleiotropic effects of sodium glucose cotransporter 2 inhibitors: head-to-head comparisons with dipeptidyl peptidase-4 inhibitors in type 2 diabetes patients

  SGLT2 inhibitors DPP4 inhibitors P value
Patients, n 2028 8112  
Age, mean years (SD) 60.9 (11.8) 61.3 (12.6) 0.285
Female, n (%) 1125 (55.5) 4617 (56.9) 0.241
HbA1c, mean % (SD) 8.7 (1.8) 8.6 (1.9) 0.063
Body weight, mean kg (SD) 71.6 (13.7) 70.9 (14.1) 0.070
SBP, mean mmHg (SD) 138.5 (19.9) 138.6 (20.5) 0.830
ALT, mean U/l (SD) 34.3 (32.2) 32.9 (31.2) 0.069
eGFR, mean ml/min/1.73 m2 (SD) 92.2 (29.4) 89.9 (39.0) 0.004
Hospital levels, n (%) 0.487
 Medical centers 1116 (55.0) 4583 (56.5)  
 Regional hospitals 537 (26.5) 2069 (25.5)  
 District hospitals 375 (18.5) 1460 (18.0)  
Cardiovascular diseases, n (%)
 Hypertension 1335 (65.8) 5336 (65.8) 0.967
 Hyperlipidemia 1312 (64.7) 5418 (66.8) 0.074
 Coronary heart disease 396 (19.5) 1543 (19.0) 0.605
 Peripheral artery disease 25 (1.2) 143 (1.8) 0.094
 Heart failure 131 (6.5) 539 (6.6) 0.764
 Ischemic stroke 91 (4.5) 355 (4.4) 0.828
Diabetes complications, n (%)
 Diabetic retinopathy 117 (5.8) 529 (6.5) 0.215
 Diabetic neuropathy 159 (7.8) 670 (8.3) 0.538
 Diabetic nephropathy 373 (18.4) 1516 (18.7) 0.760
Liver cirrhosis 54 (2.7) 165 (2.0) 0.082
Cancer 180 (8.9) 679 (8.4) 0.465
CCI score, mean (SD) 2.5 (1.6) 2.5 (1.6) 0.546
Previous hospitalization, n (%) 436 (21.5) 1637 (20.2) 0.188
Background anti-diabetes medications, n (%)
 Metformin 1691 (83.4) 6805 (83.9) 0.581
 Sulfonylurea 887 (43.7) 3458 (42.6) 0.367
 Glinide 49 (2.4) 187 (2.3) 0.767
 Acarbose 203 (10.0) 780 (9.6) 0.591
 Thiazolidinediones 122 (6.0) 466 (5.7) 0.640
 Glucagon-like peptide-1 receptors antagonist 2 (0.1) 5 (0.1) 0.571
 Insulin 331 (16.3) 1382 (17.0) 0.442
Background cardiovascular medications, n (%)
 Antiplatelet agents 602 (29.7) 2399 (29.6) 0.922
 Beta blockers 516 (25.4) 1986 (24.5) 0.369
 Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers 1117 (55.1) 4432 (54.6) 0.720
 Calcium channel blockers 794 (39.2) 3093 (38.1) 0.397
 Diuretics 244 (12.0) 971 (12.0) 0.939
 Statin 1156 (57.0) 4792 (59.1) 0.090
 Fibrate 157 (7.7) 668 (8.2) 0.468
 Ezetimibe 189 (9.3) 718 (8.9) 0.509
  1. ALT alanine aminotransferase, CCI Charlson comorbidity index, eGFR estimated glomerular filtration rate, SBP systolic blood pressures