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Table 1 Baseline characteristics after propensity score matching

From: Favorable pleiotropic effects of sodium glucose cotransporter 2 inhibitors: head-to-head comparisons with dipeptidyl peptidase-4 inhibitors in type 2 diabetes patients

 SGLT2 inhibitorsDPP4 inhibitorsP value
Patients, n20288112 
Age, mean years (SD)60.9 (11.8)61.3 (12.6)0.285
Female, n (%)1125 (55.5)4617 (56.9)0.241
HbA1c, mean % (SD)8.7 (1.8)8.6 (1.9)0.063
Body weight, mean kg (SD)71.6 (13.7)70.9 (14.1)0.070
SBP, mean mmHg (SD)138.5 (19.9)138.6 (20.5)0.830
ALT, mean U/l (SD)34.3 (32.2)32.9 (31.2)0.069
eGFR, mean ml/min/1.73 m2 (SD)92.2 (29.4)89.9 (39.0)0.004
Hospital levels, n (%)0.487
 Medical centers1116 (55.0)4583 (56.5) 
 Regional hospitals537 (26.5)2069 (25.5) 
 District hospitals375 (18.5)1460 (18.0) 
Cardiovascular diseases, n (%)
 Hypertension1335 (65.8)5336 (65.8)0.967
 Hyperlipidemia1312 (64.7)5418 (66.8)0.074
 Coronary heart disease396 (19.5)1543 (19.0)0.605
 Peripheral artery disease25 (1.2)143 (1.8)0.094
 Heart failure131 (6.5)539 (6.6)0.764
 Ischemic stroke91 (4.5)355 (4.4)0.828
Diabetes complications, n (%)
 Diabetic retinopathy117 (5.8)529 (6.5)0.215
 Diabetic neuropathy159 (7.8)670 (8.3)0.538
 Diabetic nephropathy373 (18.4)1516 (18.7)0.760
Liver cirrhosis54 (2.7)165 (2.0)0.082
Cancer180 (8.9)679 (8.4)0.465
CCI score, mean (SD)2.5 (1.6)2.5 (1.6)0.546
Previous hospitalization, n (%)436 (21.5)1637 (20.2)0.188
Background anti-diabetes medications, n (%)
 Metformin1691 (83.4)6805 (83.9)0.581
 Sulfonylurea887 (43.7)3458 (42.6)0.367
 Glinide49 (2.4)187 (2.3)0.767
 Acarbose203 (10.0)780 (9.6)0.591
 Thiazolidinediones122 (6.0)466 (5.7)0.640
 Glucagon-like peptide-1 receptors antagonist2 (0.1)5 (0.1)0.571
 Insulin331 (16.3)1382 (17.0)0.442
Background cardiovascular medications, n (%)
 Antiplatelet agents602 (29.7)2399 (29.6)0.922
 Beta blockers516 (25.4)1986 (24.5)0.369
 Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers1117 (55.1)4432 (54.6)0.720
 Calcium channel blockers794 (39.2)3093 (38.1)0.397
 Diuretics244 (12.0)971 (12.0)0.939
 Statin1156 (57.0)4792 (59.1)0.090
 Fibrate157 (7.7)668 (8.2)0.468
 Ezetimibe189 (9.3)718 (8.9)0.509
  1. ALT alanine aminotransferase, CCI Charlson comorbidity index, eGFR estimated glomerular filtration rate, SBP systolic blood pressures