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Table 3 Risk factors for atherosclerosis among individuals of European ancestry in the MCCD cohort

From: Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes

 

ORa for atherosclerosis

OR 95% C.I.

p value

Multivessel stenosis

 CHD PRS (per SD increase)

1.65

1.25–2.20

4.9e–04

 Men

3.32

1.84-6.08

8.0e–05

 Age (per year increase)

1.03

1.00–1.06

3.8e–02

 Royal Victoria Hospitalb

0.40

0.22–0.73

2.7e–03

Graded atherosclerosis severity

 CHD PRS (per SD increase)

1.35

1.08–1.69

9.4e–03

 Men

3.22

1.91–5.50

1.3e–05

 Age (per year increase)

1.02

1.00–1.04

6.0e–02

 Royal Victoria Hospital

0.39

0.23–0.64

2.2e–04

  1. aOdds ratio estimated by multivariate logistic regression, based on 310 individuals with a European ancestry
  2. bBeing recruited at the Royal Victoria Hospital
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Cardiovascular Diabetology

ISSN: 1475-2840