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Table 2 Clinical characteristics in the MCCD cohort

From: Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes

 

Patients (n = 352)

Patients with information (%)

Multivessel stenosis (%)

236 (67.1)

352 (100)

Median number of significant lesions (IQR)

2 (1–4)

352 (100)

Severity of atherosclerosis

 

352 (100)

 0–1 (%)

116 (33.0)

 

 2 (%)

68 (19.3)

 

 3 (%)

61 (17.3)

 

  ≥ 4 (%)

107 (30.4)

 

Mean PRSa (SD)

17.18 (0.10)

352 (100)

Men (%)

269 (76.4)

352 (100)

Median age (IQR)

71 (66–78)

352 (100)

European (%)

310 (88.1)

352 (100)

Hypertension (%)

328 (93.2)

352 (100)

 Systolic hypertension (%)

149 (42.7)

349 (99.1)

 Diastolic hypertension (%)

16 (4.6)

349 (99.1)

 Antihypertensive drug usage (%)

311 (88.4)

352 (100)

Hyperlipidemia (%)

333 (94.9)

351 (99.7)

 High LDL (%)

146 (42.8)

341 (96.9)

 Hypertriglyceridemia (%)

2 (0.5)

347 (98.6)

 Lipid-lowering drug usage (%)

296 (84.1)

352 (100)

Poor glycemic control (%)

48 (14.0)

343 (97.4)

Median BMI (IQR)

29.82 (26.15–33.90)

346 (98.3)

Ex- or current smokersb (%)

197 (56.0)

352 (100)

Median type 2 diabetes durationb (IQR)

15 (8–22)

189 (53.7)

Median age of type 2 diabetes diagnosisb (IQR)

58 (47–64)

189 (53.7)

Family history of heart diseaseb (%)

209 (73.9)

283 (83.4)

  1. aOriginal PRS is reported in this table. Downstream analyses adopted standardized PRS
  2. bBased on self-reported medical histories