Fig. 6
From: Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
a Example image sequence of ROS measurements in LA cardiomyocytes (shown: HFpEF). b Representative example and c related data of ROS production after 1 h incubation in glucose-deprived buffer (man) and after 30 s of glucose reintroduction (glc). d Mitochondrial fission of LA cardiomyocytes after 1 h incubation in glucose-deprived buffer (man) and after 60 s of glucose reintroduction (glc). e Representative examples of CaT at 1 Hz electric stimulation before (left) and 3 min after glycolytic inhibition with 2-deoxyglucose (2DG; right). Red, dashed lines indicate CaT peak (upper) and diastolic Ca2+ (lower) at baseline, arrows indicate stimulation triggers. Related data of f diastolic Ca2+ and (H) CaT amplitude before (glc) and after glycolytic inhibition (2DG); g corresponding change of diastolic Ca2+ and (I) CaT amplitude. Statistical analysis: Two-way ANOVA followed by post-hoc Bonferroni. p-values: 1< 0.001, 20.046, 30.015, 40.005, 50.007, 60.01, 70.04, 80.02, 90.016. n = cells derived from 6 animals per group