| |
Abnormal HOMA-IR
|
DM
|
|---|
|
Odds ratio (95% CI)
|
p value
|
Odds ratio (95% CI)
|
p value
|
|---|
|
Univariable
|
4.52 (2.58–7.91)
|
< 0.001
|
5.87 (3.08–11.2)
|
< 0.001
|
|
Model 1
|
3.49 (1.97–6.20)
|
< 0.001
|
4.05 (2.07–7.92)
|
< 0.001
|
|
BMI adjusted model
|
|
Model 2
|
2.34 (1.26–4.34)
|
0.007
|
2.97 (1.45–6.09)
|
0.003
|
|
Model 3
|
2.37 (1.27–4.42)
|
0.006
|
2.95 (1.44–6.06)
|
0.003
|
|
Model 4
|
2.38 (1.27–4.44)
|
0.007
|
3.02 (1.46–6.24)
|
0.003
|
|
WC adjusted model
|
|
Model 2
|
2.21 (1.17–4.15)
|
0.014
|
2.75 (1.33–5.68)
|
0.006
|
|
Model 3
|
2.24 (1.19–4.23)
|
0.013
|
2.73 (1.32–5.63)
|
0.007
|
|
Model 4
|
2.23 (1.18–4.22)
|
0.013
|
2.80 (1.35–5.81)
|
0.006
|
- Reference; normal HOMA-IR
- Model 1: adjusted for age and sex
- Model 2: adjusted for Model 1 plus hypertension, hyperlipidemia, smoking status and BMI (BMI adjusted model) or WC (WC-adjusted model)
- Model 3: adjusted for Model 2 plus echocardiographic parameters including LV mass index and E/e′
- Model 4: adjusted for Model 3 plus serum CRP and eGFR
- BMI body mass index, CI confidence interval, CRP C-reactive protein, DM diabetes mellitus, E early diastolic transmitral flow velocity, e′ early diastolic mitral annular velocity, eGFR estimated glomerular filtration rate, GLS global longitudinal strain, HOMA-IR homeostatic model assessment of insulin resistance, LV left ventricle, WC waist circumference
