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Table 2 Association between glycemic abnormality and impaired LVGLS (>ā€‰āˆ’ā€‰16.65%)

From: Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community

Ā 

Abnormal HOMA-IR

DM

Odds ratio (95% CI)

p value

Odds ratio (95% CI)

p value

Univariable

4.52 (2.58ā€“7.91)

ā€‰<ā€‰0.001

5.87 (3.08ā€“11.2)

ā€‰<ā€‰0.001

Model 1

3.49 (1.97ā€“6.20)

ā€‰<ā€‰0.001

4.05 (2.07ā€“7.92)

ā€‰<ā€‰0.001

BMI adjusted model

Ā Model 2

2.34 (1.26ā€“4.34)

0.007

2.97 (1.45ā€“6.09)

0.003

Ā Model 3

2.37 (1.27ā€“4.42)

0.006

2.95 (1.44ā€“6.06)

0.003

Ā Model 4

2.38 (1.27ā€“4.44)

0.007

3.02 (1.46ā€“6.24)

0.003

WC adjusted model

Ā Model 2

2.21 (1.17ā€“4.15)

0.014

2.75 (1.33ā€“5.68)

0.006

Ā Model 3

2.24 (1.19ā€“4.23)

0.013

2.73 (1.32ā€“5.63)

0.007

Ā Model 4

2.23 (1.18ā€“4.22)

0.013

2.80 (1.35ā€“5.81)

0.006

  1. Reference; normal HOMA-IR
  2. Model 1: adjusted for age and sex
  3. Model 2: adjusted for Model 1 plus hypertension, hyperlipidemia, smoking status and BMI (BMI adjusted model) or WC (WC-adjusted model)
  4. Model 3: adjusted for Model 2 plus echocardiographic parameters including LV mass index and E/eā€²
  5. Model 4: adjusted for Model 3 plus serum CRP and eGFR
  6. BMI body mass index, CIā€‰confidence interval, CRPā€‰C-reactive protein, DM diabetes mellitus, Eā€‰ early diastolic transmitral flow velocity, eā€²ā€‰early diastolic mitral annular velocity, eGFRā€‰ estimated glomerular filtration rate, GLSā€‰global longitudinal strain, HOMA-IRā€‰ homeostatic model assessment of insulin resistance, LV left ventricle, WC waist circumference