Ā | Abnormal HOMA-IR | DM |
---|
Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value |
---|
Univariable | 4.52 (2.58ā7.91) | ā<ā0.001 | 5.87 (3.08ā11.2) | ā<ā0.001 |
Model 1 | 3.49 (1.97ā6.20) | ā<ā0.001 | 4.05 (2.07ā7.92) | ā<ā0.001 |
BMI adjusted model |
Ā Model 2 | 2.34 (1.26ā4.34) | 0.007 | 2.97 (1.45ā6.09) | 0.003 |
Ā Model 3 | 2.37 (1.27ā4.42) | 0.006 | 2.95 (1.44ā6.06) | 0.003 |
Ā Model 4 | 2.38 (1.27ā4.44) | 0.007 | 3.02 (1.46ā6.24) | 0.003 |
WC adjusted model |
Ā Model 2 | 2.21 (1.17ā4.15) | 0.014 | 2.75 (1.33ā5.68) | 0.006 |
Ā Model 3 | 2.24 (1.19ā4.23) | 0.013 | 2.73 (1.32ā5.63) | 0.007 |
Ā Model 4 | 2.23 (1.18ā4.22) | 0.013 | 2.80 (1.35ā5.81) | 0.006 |
- Reference; normal HOMA-IR
- Model 1: adjusted for age and sex
- Model 2: adjusted for Model 1 plus hypertension, hyperlipidemia, smoking status and BMI (BMI adjusted model) or WC (WC-adjusted model)
- Model 3: adjusted for Model 2 plus echocardiographic parameters including LV mass index and E/eā²
- Model 4: adjusted for Model 3 plus serum CRP and eGFR
- BMI body mass index, CIāconfidence interval, CRPāC-reactive protein, DM diabetes mellitus, Eā early diastolic transmitral flow velocity, eā²āearly diastolic mitral annular velocity, eGFRā estimated glomerular filtration rate, GLSāglobal longitudinal strain, HOMA-IRā homeostatic model assessment of insulin resistance, LV left ventricle, WC waist circumference