Parameter | Placebo | Apabetalone | P value |
---|---|---|---|
HbA1c | |||
 Baseline (%) | 7.3 (6.4–8.6) | 7.4 (6.4–8.7) |  |
 Follow up (%) | 7.2 (6.4–8.4) | 7.2 (6.4–8.5) |  |
 Absolute change (%) | 0.00 [− 0.10, 0.05] | − 0.05 [− 0.15, 0.00] | 0.18 |
 Percent change (%) | 0.04 [− 0.76, 0.88] | − 0.63 [− 1.49, 0.25] | 0.25 |
LDL-C | |||
 Baseline (mg/dL) | 70.9 ± 32.4 | 69.7 ± 29.8 |  |
 Follow up (mg/dL) | 63.6 ± 29.4 | 63.4 ± 28.3 |  |
 Absolute change (mg/dL) | − 6.55 [− 8.00, − 5.10] | − 6.34 [− 7.79, − 4.89] | 0.37 |
 Percent change (%) | − 0.31 [− 4.13, 3.50] | − 1.57 [− 2.25, 5.38] | 0.28 |
HDL-C | |||
 Baseline (mg/dL) | 33.3 ± 5.1 | 33.3 ± 5.1 |  |
 Follow up (mg/dL) | 36.6 ± 7.5 | 38.0 ± 8.0 |  |
 Absolute change (mg/dL) | 3.34 [2.93, 3.75] | 4.75 [4.34, 5.15] | < 0.0001 |
 Percent change (%) | 10.9 [9.62, 12.2] | 15.4 [14.1, 16.7] | < 0.0001 |
hsCRP | |||
 Baseline (mg/L) | 2.7 (1.1–6.1) | 2.9 (1.3–5.9) |  |
 Follow up (mg/L) | 1.8 (1.0–4.3) | 1.8 (0.9–3.9) |  |
 Absolute change (mg/L) | − 0.53 [− 0.93, − 0.24] | − 0.80 [− 1.3, − 0.44] | 0.34 |
 Percent change (%) | − 11.3 [− 20.0, − 1.5] | − 18.4 [− 28.0, − 7.1] | 0.16 |
ALP | |||
 Baseline (U/L) | 81.9 ± 34.7 | 83.3 ± 38.2 |  |
 Follow up (U/L) | 79.5 ± 29.5 | 74.3 ± 43.2 |  |
 Absolute change (U/L) | − 2.20 [− 3.60, − 0.81] | − 8.98 [− 10.4, − 7.59] | < 0.0001 |
 Percent change (%) | 4.22 [0.27, 8.18] | − 8.31 [− 12.2, − 4.37] | < 0.0001 |
eGFR | |||
 Baseline (mL/min) | 102 ± 38.6 | 105 ± 39.2 |  |
 Follow up (mL/min) | 105 ± 40.2 | 106 ± 41.9 |  |
 Absolute change (mL/min) | 2.02 [0.97, 3.07] | − 0.33 [− 1.38, 1.72] | 0.001 |
 Percent change (%) | 3.03 [1.87, 4.18] | − 0.46 [− 0.70, 1.61] | 0.001 |