Subgroup analysis | Subjects | ||||||
---|---|---|---|---|---|---|---|
SGLT-2 inhibitors | GLP-1 RAs | Comparison | Risk ratio | 95% CI | I2 (%) | p value | |
MACE-3 | |||||||
 eGFR 30-44 | 2479 | 1934 | SGLT-2 inhibitors vs. placebo | 0.73 | 0.54–0.97 | 57.1 | 0.063 |
 |  | GLP-1 RAs vs. placebo | 1.02 | 0.78–1.33 |  |  | |
 |  | SGLT-2 inhibitors vs. GLP-1 RAs | 0.72 | 0.48–1.06 |  |  | |
 eGFR 45-59 | 3974 | 4576 | SGLT-2 inhibitors vs. placebo | 0.82 | 0.66–1.01 | 44.8 | 0.12 |
 |  | GLP-1 RAs vs. placebo | 0.85 | 0.71–1.03 |  |  | |
 |  | SGLT-2 inhibitors vs. GLP-1 RAs | 0.96 | 0.72–1.27 |  |  | |
Renal outcomes | |||||||
 eGFR 30-44 | 2420 | 889 | SGLT-2 inhibitors vs. placebo | 0.75 | 0.62–0.91 | 0 | 0.69 |
 |  | GLP-1 RAs vs. placebo | 0.78 | 0.46–1.32 |  |  | |
 |  | SGLT-2 inhibitors vs. GLP-1 RAs | 0.96 | 0.55–1.29 |  |  | |
 eGFR 45-59 | 3976 | 2288 | SGLT-2 inhibitors vs. placebo | 0.61 | 0.48–0.77 | 0 | 0.52 |
 |  | GLP-1 RAs vs. placebo | 1.18 | 0.76–1.84 |  |  | |
 |  | SGLT-2 inhibitors vs. GLP-1 RAs | 0.52 | 0.31–0.85 |  |  |