Skip to main content

Table 2 Baseline characteristics of included studies in patients with GFR < 60 ml/min/1.73 m2

From: Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta-analysis

Study Number of patients (GFR < 60) Age Male (%) BMI sBP (mmHg) dBP (mm Hg) HgbA1c (%) GFR < 30 (%) GFR 30-45 (%) GFR 45-60 (%) Median GFR in CKD UACR (mg/g) Noormo-albuminuria (%) Microalbuminuria (%) Macroalbuminuria (%)
SGLT2i vs placebo
 CANVAS Program 2039 67.6 58.2 32.3 138 75 8.2 0.0 27.2 72.8 49.1 24.4 55.4 N/A N/A
 CREDENCE 2592 63.8 66.5 31.3 140 78 8.2 0.0 45.3 48.1 45.1 1012 N/A N/A N/A
 DECLARE-TIMI 58 1265 67.3 64.3 34.5 134 75 8.2 N/A N/A N/A 51.4 N/A 55.6 30.9 13.5
 EMPA-REG OUTCOME 1819 67.1 72.8 30.6 138 76 8.1 0 31.3 68.7 N/A N/A 47.7 33.9 18.4
 SCORED 10,584 69.0 55.1 31.8 138 78 8.3 7.7 43.9 48.3 44.5 74.5 35.1 33.9 31.0
 VERTIS-CV 1807 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
 Weighted average (SGLT-2 inhibitors) 67.8 59.5 31.9 137.9 77.2 8.2   40.8 53.4    40.8 33.6 27.7
GLP-1 RA vs placebo
 ELIXA 1399 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 59.7 25.5 14.8
 EXSCEL 3177 66.5 57.1 32.8 N/A N/A 8.1 0 28.0 72.0 49.2 N/A 71.4 19.6 9.0
 HARMONY Outcomes 2222 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
 LEADER 2158 67.3 61.3 32.7 136.4 75.1 8.6 10.4 29.0 60.6 45.6 49.5 47.6 29 23.4
 PIONEER-6 856 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
 REWIND 2199 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
 SUSTAIN-6 832 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
 Weighted average (GLP-1 RAs) 66.8 58.8 32.8    8.3   28.4 67.4    61.3 23.8 14.8
  1. Normoalbuminuria, microlabuminuria and macroalbuminuria defined as < 30, 30–299, and ≥ 300 mg/g creatinine, respectively
  2. SGLT2i sodium-glucose cotransporter-2 inhibitors, GLP-1 RAs glucagon-like peptide-1 receptor agonists, GFR glomerular filtration rate, BMI body mass index, sBP systolic blood pressure, dBP diastolic blood pressure, Hgb A1c hemoglobin A1c, UACR urine albumin-to-creatinine ratio, N/A not available