Table 2 Hazard ratios for the primary outcome based on different GA variability metrics
GA variability indicators tertiles | P value for trend | Per 1 unit increase | |||
|---|---|---|---|---|---|
T1 | T2 | T3 | |||
CV | < 7.35 | 7.35–12.47 | ≥ 12.48 | – | – |
No. of participants | 144 | 145 | 147 | – | – |
No. of cases | 31 | 32 | 49 | – | – |
Person-years | 510 | 507 | 475 | – | – |
Age and sex-adjusted HRs | 1.00 | 1.02 (0.62–1.68) | 1.74 (1.10–2.73) | 0.019 | 1.03 (1.01–1.06) |
Multivariable adjusted HRs | 1.00 | 1.06 (0.65–1.75) | 1.71(1.07–2.73) | 0.042 | 1.03 (1.01–1.06) |
VIM | < 0.61 | 0.61–1.12 | ≥ 1.13 | – | – |
No. of participants | 146 | 144 | 146 | – | – |
No. of cases | 32 | 31 | 49 | – | – |
Person-years | 521 | 521 | 451 | – | – |
Age and sex-adjusted HRs | 1.00 | 0.95 (0.58–1.57) | 1.85 (1.19–2.89) | 0.004 | 1.40 (1.12–1.76) |
Multivariable adjusted HRs | 1.00 | 0.99 (0.60–1.64) | 1.65 (1.02–2.67) | 0.050 | 1.32 (1.03–1.69) |
ARV | < 1.75 | 1.75–3.29 | ≥ 3.30 | – | – |
No. of participants | 145 | 146 | 145 | – | – |
No. of cases | 29 | 33 | 50 | – | – |
Person-years | 510 | 523 | 460 | – | – |
Age and sex-adjusted HRs | 1.00 | 1.11 (0.67–1.82) | 1.97 (1.24–3.12) | 0.005 | 1.10 (1.03–1.18) |
Multivariable adjusted HRs | 1.00 | 1.08 (0.64–1.81) | 1.81 (1.08–3.04) | 0.032 | 1.07 (1.01–1.15) |