Table 1 general, demographic and laboratory variables in subjects treated with dulaglutide vs. controls ( conventional therapy)
Variables | Subjects treated with conventional therapy + dulaglutide (n = 56) | Controls (conventional therapy) (n = 56) | p | |
|---|---|---|---|---|
Age (years) (mean ± SD) | 69.7 ± 8.6 | 67.6 ± 5.1 | 0.111 | |
M/F (n/%) | 24/32 (42.8/57.2) | 21/35 (37.5/62.5) | 0.700 | |
SBP (mm/Hg) (mean ± SD) | 137.8 ± 12.1 | 133.9 ± 12.3 | 0.087 | |
DBP (mm/Hg) (mean ± SD) | 76.3 ± 12.3 | 79.8 ± 7.7 | 0.071 | |
Weight (Kg) (mean ± SD) | 75.7 ± 8.5 | 76.6 ± 7.5 | 0.562 | |
BMI (kg/m²) (mean ± SD) | 27.6 ± 3.4 | 27.9 ± 3.2 | 0.563 | |
HR (bpm) (mean ± SD) | 76.6 ± 11.1 | 79.3 ± 15.8 | 0.299 | |
Total cholesterol (mg/dL) (mmol/L) (mean ± SD) | 160.9 ± 20.5/4.2 ± 0.5 | 167.8 ± 25.8/4.3 ± 0.7 | 0.121 | |
HDL cholesterol (mmol/L) (mean ± SD) | 37.4 ± 4.3/0.9 ± 0.1 | 37.5 ± 4.5/0.9 ± 0.2 | 0.961 | |
LDL cholesterol (mmol/L) (mean ± SD) | 102.7 ± 11.6/2.6 ± 0.3 | 104.5 ± 13.5 /2.7 ± 0.4 | 0.439 | |
Triglycerides (mmol/L) (mean ± SD) | 139.2 ± 13.6/1.6 ± 0.2 | 138.9 ± 13.6/1.6 ± 0.2 | 0.910 | |
FPG ( mg/dL/ mmol/L (mean ± SD) | 147.6 ± 32.6 /8.2 ± 1.2 | 144.7 ± 31.5 /8.1 ± 1.8 | 0.626 | |
HBa1C ( %) (mean ± SD) | 7.4 ± 0.7 | 7.2 ± 0.6 | 0.101 | |
eGFR CKD-EPI (mL/min per 1·73 m²) (mean ± SD) | 77.4 ± 11.2 | 76.1 ± 16.9 | 0.640 | |
Microalbuminuria (mg/24 h) (mean ± SD) | 80.9 ± 20.9 | 73.1 ± 29.2 | 0.107 | |
RHI (mean ± SD) | 1.7 ± 0.4 | 1.8 ± 0.7 | 0.275 | |
PWV (m/s) (mean ± SD) | 11.2 ± 0.9 | 10.9 ± 0.8 | 0.193 | |
Aix ( %) (mean ± SD) | 105.6 ± 6.9 | 103.9 ± 4.4 | 0.121 | |
Hypertension (n/%) | 45/80.3 | 35/62.5 | 0.700 | |
Diabetes (n/%) | 56/100 | 56/100 | – | |
Duration of diabetes (years) (mean ± SD) | 10.4 ± 3.3 | 10.2 ± 4.0 | 0.773 | |
Dyslipidaemia (n/%) | 32 (57.1) | 29 (51.8) | 0.704 | |
Hypercholesterolaemia (n/%) | 31 (55.3) | 27 (48.2) | 0.570 | |
Smoking (n/%) | 12 (21.4) | 13 (23.2) | 1.0 | |
Microalbuminuria | 12 (21.4) | 11 (19.6) | 1.0 | |
Macroalbuminuria | 4 (7.1) | 3 (5.4) | 1.0 | |
Metformin (n/%) | 50 (89.3) | 49 ( 87.5) | 1.0 | |
Sulfoniluree (n/%) | 31 (55.3) | 30 (53.6) | 1.0 | |
Insulin (n/%) | 12 (21.4) | 11 (19.6) | 1.0 | |
ACEi (n/%) | 28 (50.0) | 32 (57.1) | 0.569 | |
Beta blockers (n/%) | 28 (50.0) | 24 (42.8) | 0.570 | |
CCB (n/%) | 21 (37.5) | 22 (39.3) | 1.0 | |
Antiplatelets (n/%) | 23 (41.1) | 18 (32.1) | 0.432 | |
Anticoagulants (n/%) | 30 (53.6) | 30 (53.6) | 1.0 | |
Diuretics(n/%) | 27 (48.2) | 30 (53.6) | 0.705 | |
Statins (n/%) | 22 (39.3) | 16 (28.6) | 0.318 | |