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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Correction to: Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Fig. 4

Effects of pitavastatin, pemafibrate or combination of pitavastatin and pemafibrate on endothelium-dependent vascular relaxations in response to acetylcholine. Rats were fed a normal diet (ND) or a high-salt and high-fat diet (HD). The rats were divided into five groups and treated with a vehicle, pitavastatin, pemafibrate (K-877), or combination of pitavastatin and pemafibrate. Data are expressed as the mean ± SD. *P < 0.001, HD-vehicle group versus ND-vehicle group. #P < 0.05, HD-combination group versus HD-vehicle group. Number of rats in each group: ND-vehicle, n = 4; HD-vehicle, n = 5; HD-pitavastatin, n = 5; HD-pemafibrate, n = 5; and HD-combination, n = 5. Statistical analysis was performed using mixed effect model with a Bonferroni post-hoc test

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Cardiovascular Diabetology

ISSN: 1475-2840