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Table 3 Univariate and Multivariate Cox regression analysis for CRTd responders (a), hospitalization for HF worsening (b), cardiac deaths (c) and all cause of deaths (d)

From: Cardiac resynchronization therapy and its effects in patients with type 2 DIAbetes mellitus OPTimized in automatic vs. echo guided approach. Data from the DIA-OPTA investigators

 

Univariate analysis HR (95% CI)

p value

Multivariate analysis HR (95% CI)

p value

A. Multivariate Cox regression analysis for parameters associated with CRT responders

 Age

0.102 [0.11–0.968]

0.048

0.713 [0.007–1.773]

0.276

 Automatic

0.795 [0.567–1.115]

0.184

3.636 [1.271–10.399]

0.016*

 Beta blockers

1.176 [0.806–1.716]

0.401

1.156 [0.745–1.793]

0.517

 BNP

1.001 [0.989–1.101]

0.868

1.001 [0.889–1.007]

0.816

 COPD

1.446 [0.948–2.204]

0.087

1.527 [0.935–2.495]

0.091

 CRP

1.101 [0.992–1.280]

0.274

1.017 [0.995–1.041]

0.136

 HbA1c

1.118 [0.851–1.315]

0.643

1.181 [0.922–1.472]

0.123

 Hypertension

0.898 [0.619–1.302]

0.569

0.895 [0.561–1.430]

0.644

 LVEF

1.006 [0.970–1.044]

0.736

1.036 [0.993–1.081]

0.102

 NYHA 3

1.176 [0.840–1.647]

0.345

1.829 [0.923–3.626]

0.084

 Obesity

1.497 [1.290–1.852]

0.011

1.330 [0.829–1.843]

0.082

 QRS duration

0.989 [0.971–1.008]

0.255

0.991 [0.971–1.011]

0.379

 SonR

10.2 [5.227–19.952]

0.002

2.863 [1.537–6.231]

0.006*

 6MWT

1.001 [0.993–1.007]

0.926

1.010 [0.993–1.007]

0.994

B. Multivariate Cox regression analysis for parameters associated with hospitalizations for heart failure

 Age

1.012 [0.873–1.322]

0.958

0.997 [0.671–1.201]

0.240

 Automatic

0.795 [0.567–1.115]

0.184

1.166 [0.118–1.504]

0.895

 Beta blockers

1.301 [0.587–2.885]

0.517

0.844 [0.336–2.122]

0.718

 BNP

1.002 [1.001–1.301]

0.011

1.002 [1.001–1.040]

0.125

 COPD

0.561 [0.276–1.141]

0.111

2.364 [0.907–6.158]

0.078

 CRP

1.011 [0.978–1.046]

0.507

1.032 [0.982–1.084]

0.219

 HbA1c

1.142 [0.816–1.913]

0.143

0.915 [0.589–1.541]

0.762

 Hypertension

1.991 [1.003–3.952]

0.049

2.503 [0.809–7.745]

0.111

 LVEF

1.029 [0.956–1.108]

0.443

1.061 [0.960–1.172]

0.245

 NYHA 3

0.531 [0.258–1.096]

0.087

0.962 [0.289–3.202]

0.950

 Obesity

0.905 [0.276–2.965]

0.869

1.093 [0.220–5.429]

0.913

 QRS duration

0.964 [0.927–1.020]

0.066

0.960 [0.919–1.003]

0.069

 SonR

0.074 [0.004–1.292]

0.074

0.679 [0.118–1.154]

0.932

 6MWT

0.999 [0.985–1.013]

0.891

0.995 [0.980–1.011]

0.552

C. Multivariate Cox regression analysis for parameters associated with cardiac deaths

 Age

0.953 [0.795–1.541]

0.543

1.362 [0.632–1.872]

0.361

 Automatic

1.670 [0.489–5.705]

0.413

0.111 [0.001–2.583]

0.427

 Beta blockers

2.099 [0.525–3.024]

0.176

1.095 [0.048–1.435]

0.945

 BNP

1.001 [0.998–1.004]

0.681

0.999 [0.996–1.003]

0.679

 COPD

1.119 [0.031–1.447]

0.072

2.138 [0.942–4.002]

0.401

 CRP

0.913 [0.807–1.034]

0.151

0.903 [0.734–1.112]

0.338

 HbA1c

1.601 [0.925–2.563]

0.142

3.224 [0.841–4.389]

0.106

 Hypertension

0.226 [0.029–1.764]

0.156

0.515 [0.026–1.019]

0.663

 LVEF

1.127 [0.964–1.316]

0.133

1.126 [0.855–1.482]

0.397

 NYHA 3

0.615 [0.180–2.102]

0.439

0.458 [0.008–2.618]

0.705

 Obesity

2.283 [0.002–3.248]

0.521

0.759 [0.001–1.621]

0.993

 QRS duration

0.951 [0.885–1.021]

0.164

0.897 [0.782–1.016]

0.087

 SonR

0.056 [0.001–8.699]

0.263

0.010 [0.001–5.267]

0.520

 6MWT

0.992 [0.968–1.016]

0.509

0.973 [0.919–1.031]

0.355

D. Multivariate Cox regression analysis for parameters associated with all cause deaths

 Age

1.782 [1.053–2.302]

0.001

1.362 [0.809–1.780]

0.563

 Automatic

1.471 [0.570–3.795]

0.425

1.744 [0.270–2.713]

0.179

 Beta blockers

2.009 [0.582–6.490]

0.270

3.338 [0.684–6.781]

0.096

 BNP

0.999 [0.996–1.002]

0.434

0.998 [0.994–1.021]

0.258

 COPD

0.268 [0.106–0.680]

0.006

2.802 [0.493–5.192]

0.245

 CRP

0.918 [0.837–1.007]

0.070

0.915 [0.792–1.057]

0.915

 HbA1c

0.832 [0.503–1.742]

0.430

0.587 [0.201–3.105]

0.224

 Hypertension

0.027 [0.001–1.801]

0.092

0.898 [0.648–1.547]

0.936

 LVEF

1.008 [0.916–1.110]

0.869

0.879 [0.001–5.644]

0.713

 NYHA 3

0.292 [0.096–0.888]

0.030

1.966 [0.030–3.082]

0.465

 Obesity

2.289 [0.014–3.766]

0.407

0.468 [0.009–1.821]

0.099

 QRS duration

0.958 [0.907–1.012]

0.128

0.958 [0.885–1.037]

0.284

 SonR

0.191 [0.005–7.540]

0.378

1.684 [0.101–5.647]

0.713

 6MWT

1.009 [0.991–1.028]

0.339

1.004 [0.977–1.031]

0.791

  1. Italic values indicate a significant p value (p < 0.05)
  2. * Is for statistical significant (p < 0.05). BNP, B type natriuretic peptide; COPD, chronic obstructive pulmonary disease; CRP, C reactive protein; HbA1c, glycated hemoglobin 1Ac type; LVEF, left ventricle ejection fraction; NYHA 3, New York Heart Association 3 class; SonR, values of SonR signals; 6MWT, 6 min walking test. Multivariate Cox regression analysis for parameters associated with CRT responders
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Cardiovascular Diabetology

ISSN: 1475-2840