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Table 1 Distribution of number MACE or non-CV deaths according to baseline characteristics

From: Total cardiovascular or fatal events in people with type 2 diabetes and cardiovascular risk factors treated with dulaglutide in the REWIND trail: a post hoc analysis

 

Participants

Number of events per participant

P (trend)

0

1

 ≥ 2

Randomized

9901

8233

1425

243

 

Mean age (years)

9901

65.8 (6.3)

68.1 (7.3)

67.9 (8.0)

 < 0.0001

Female

4589

3972 (48.2)

522 (36.6)

95 (39.1)

 < 0.0001

White

7498

6207 (75.4)

1096 (76.9)

195 (80.3)

0.044

Tobacco consumption

1407

1113 (13.5)

254 (17.8)

40 (16.5)

 < 0.0001

Prior cardiovascular disease

3114

2362 (28.7)

614 (43.1)

138 (56.8)

 < 0.0001

Hypertension

9224

7658 (93.0)

1338 (93.9)

228 (93.8)

0.23

Prior heart failure

853

626 (7.6)

184 (12.9)

43 (17.7)

 < 0.0001

Mean diabetes duration (years)

9901

10.3 (7.04)

11.4 (7.91)

11.8 (8.67)

 < 0.0001

Mean BMI (kg/m2)

9900

32.4 (5.7)

32.0 (5.78)

32.6 (6.12)

0.16

Mean SBP (mm Hg)

9901

137 (16.5)

140 (18.0)

139 (17.7)

 < 0.0001

Mean DBP (mm Hg)

9901

78.5 (9.7)

78.6 (10.3)

77.2 (10.6)

0.463

Mean HbA1c

9876

7.3 (1.0)

7.4 (1.1)

7.4 (1.0)

0.0062

Mean eGFR (mL/min per 1.73 m2)

9640

77.9 (22.3)

71.7 (24.0)

70.7 (23.8)

 < 0.0001

Mean LDL (mmol/L)

9590

2.55 (0.97)

2.64 (1.00)

2.48 (0.96)

0.092

Medications

 Metformin

8037

6737 (81.8)

1111 (78.0)

189 (77.8)

0.0004

 Sulfonylurea

4552

3740 (45.4)

700 (49.1)

112 (46.1)

0.0430

 Insulin

2363

1889 (22.9)

409 (28.7)

65 (26.8)

 < 0.0001

 DPP4i

564

484 (5.9)

64 (4.5)

16 (6.6)

0.220

 Thiazolidinedione

168

150 (1.8)

14 (1.0)

4 (1.7)

0.073

 Other glucose lowering drugs

32

28 (0.3)

4 (0.3)

0

0.39

 ACEI/ARB

8068

6700 (81.4)

1166 (81.8)

202 (83.1)

0.47

 Beta blocker

4512

3628 (44.1)

737 (51.7)

147 (60.5)

 < 0.0001

 Other BP drug

5599

4568 (55.5)

871 (61.1)

160 (65.8)

 < 0.0001

 Statin

6547

5450 (66.2)

907 (63.7)

190 (78.2)

0.27

 Fibrate

898

756 (9.2)

119 (8.4)

23 (9.5)

0.52

 Antiplatelet

5342

4365 (53.0)

812 (57.0)

165 (67.9)

 < 0.0001

  1. Data are shown as N (%) or Mean (SD); BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycated hemoglobin A1c; eGFR, estimated glomerular filtration rate; LDL, low density lipoprotein; DPP4i, dipeptidyl-peptidase-4 inhibitor; ACEI/ARB, angiotensin converting enzyme inhibitor/angiotensin receptor blocker
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Cardiovascular Diabetology

ISSN: 1475-2840