Fig. 1
From: Insulin directly stimulates mitochondrial glucose oxidation in the heart
Insulin stimulation of glucose oxidation rates is independent of glycolysis in the mouse heart. a Schematic of study design for Study 1. Hearts were perfused in an isolated working heart mode for 30 min with either vehicle or insulin throughout the perfusion protocol. The metabolic profile of the heart was characterized by measuring b glycolysis, c glucose oxidation and d palmitate (fatty acid) oxidation along with e their contribution to cardiac ATP production (n = 9 for each experimental group). Arrows indicate the time of adding the vehicle of insulin to the perfusate. Individual values for each group are presented as a scattered plot along with its mean ± SEM. Data were analyzed using an unpaired student t-test. *p < 0.05 compared to the vehicle-treated hearts