Table 6 Effect of metformin on arrhythmias: ongoing clinical trials
From: Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient
| Model | Status | Type of study/No. of patients/FU | Intervention | Primary outcome | References |
|---|---|---|---|---|---|
| Patients with paroxysmal or persistent AF with CIED | Recruiting | Phase 4 Randomized clinical trial/270 patients/2 years |
- Metformin 750 mg twice daily × 2 years - Lifestyle/risk factor modification | Change in %AF burden at 1 year | [95] |
| Patients with AF who underwent AF catheter ablation | Terminated | Phase 2 Randomized clinical trial/6 patients/6 months | - Metformin 1000 mg twice daily | Number of patients who maintain sinus rhythm | [96] |