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Table 6 Effect of metformin on arrhythmias: ongoing clinical trials

From: Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient

Model

Status

Type of study/No. of patients/FU

Intervention

Primary outcome

References

Patients with paroxysmal or persistent AF with CIED

Recruiting

Phase 4 Randomized clinical trial/270 patients/2 years

- Metformin 750 mg twice daily × 2 years

- Lifestyle/risk factor modification

Change in %AF burden at 1 year

[95]

Patients with AF who underwent AF catheter ablation

Terminated

Phase 2 Randomized clinical trial/6 patients/6 months

- Metformin 1000 mg twice daily

Number of patients who maintain sinus rhythm

[96]

  1. AF atrial fibrillation, CIED cardiovascular implantable electronic device