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Table 4 Multivariable Cox regression analysis showing the association between circulating AFABP level and incident MACE

From: Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study

Model

Adjusted HR for AFABPa (95% CI)

P value

Model 1

4.25 (2.16–8.37)

< 0.01

Model 2

2.65 (1.16–6.05)

< 0.05

Model 3

2.77 (0.99–7.76)

0.05

  1. Model 1: include age, sex and body mass index at baseline
  2. Model 2: include all variables in model 1 + hypertension, dyslipidemia, chronic kidney disease and glycated haemoglobin at baseline
  3. Model 3: include all variables in model 2 + use of insulin and metformin at baseline
  4. Hypertension was defined as BP ≥ 140/90 mmHg or the use of anti-hypertensive medications. Dyslipidemia was defined as fasting triglyceride ≥ 1.69 mmol/L, high-density lipoprotein cholesterol < 1.04 mmol/L in men and < 1.29 mmol/L in women, low-density lipoprotein cholesterol ≥ 2.6 mmol/L, or the use of lipid-lowering medications. Chronic kidney disease was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2
  5. AFABP, adipocyte fatty acid-binding protein; CI, confidence interval; HR, hazard ratio; MACE, major adverse cardiovascular events
  6. aLog-transformed before analysis
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Cardiovascular Diabetology

ISSN: 1475-2840