Primary endpoint (myocardial infarction, stroke, and mortality from cardiovascular disease) | ||||
---|---|---|---|---|
IDF and AHA/NHLBI definition with specific waist circumference cut-off points for Spanish populationa | NCEP-ATPIII Metabolic Syndrome definitionb | |||
Cases | 228 | 228 | ||
Person- years of follow up | 47,838 | 47,838 | ||
Incidence rate/1000 person-year | 4.77 | 4.77 | ||
HR (95% CI)c | RAP (95% CI) | HR (95% CI)c | RAP (95% CI) | |
Metabolic syndrome and componentsd, e | ||||
Metabolic syndrome | 1.39 (1.05–1.83) | 3.64 (0.27, 7.01) | 1.36 (1.03–1.78) | 3.33 (0.10–6.56) |
Elevated waist circumference | 1.40 (1.03–1.90) | 3.66 (0.03, 7.29) | 1.30 (0.98–1.72) | 2.79 (− 0.44, 6.01) |
Elevated blood pressure | 1.64 (1.12–2.39) | 6.20 (1.37, 11.02) | 1.63 (1.12–2.35) | 6.07 (1.35, 10.80) |
Elevated fasting glucose | 1.21 (0.92–1.58) | 2.17 (− 0.93, 5.26) | 1.25 (0.94–1.66) | 2.23 (− 1.03, 5.50) |
Reduced HDL-cholesterol | 1.39 (1.02–1.89) | 3.68 (0.06, 7.29) | 1.42 (1.06–1.92) | 3.95 (0.54, 7.37) |
Elevated triglycerides | 1.38 (1.02–1.85) | 3.43 (− 0.03, 6.88) | 1.38 (1.02–1.85) | 3.41 (0.06, 6.75) |
Number of traitsd, e | ||||
0–1 trait | 1.00 (ref.) | 0.00 (ref.) | 1.00 (ref.) | 0.00 (ref.) |
2 traits | 1.62 (1.06–2.47) | 5.91 (0.65, 11.17) | 1.39 (0.98–1.96) | 3.51 (− 0.57, 7.59) |
3 traits | 1.66 (1.08–2.57) | 6.02 (0.54, 11.50) | 1.34 (0.92–1.97) | 3.11 (− 1.42, 7.64) |
4 traits | 2.06 (1.30–3.26) | 8.42 (2.49, 14.35) | 2.03 (1.31–3.15) | 7.74 (2.39, 13.09) |
5 traits | 2.57 (1.38–4.81) | 11.48 (3.64, 19.32) | 2.33 (1.19–4.58) | 9.78 (1.82, 17.80) |
Per additional trait | 1.22 (1.10–1.36) | 2.38 (0.96, 3.80) | 1.22 (1.09–1.36) | 2.31 (0.88, 3.74) |