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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Depression and cardiovascular risk—association among Beck Depression Inventory, PCSK9 levels and insulin resistance

Fig. 3

Conceptual diagram of causal mediation analysis, that hypothesized mechanism linking BDI-II and HOMA-IR. The solid black arrow represents the effect of BDI-II on HOMA-IR levels that operates directly or through a pathway different from the mediator analyzed in the current study (PCSK9). The dotted black arrows represent the suggested alternative pathway, where an indirect effect of BDI-II on HOMA-IR is mediated by PCSK9 levels. The black thin arrows indicate increased levels of HOMA-IR. BDI Beck Depression Inventory, HOMA-IR homeostasis model assessment of insulin resistance, PCSK9 pro-protein convertase subtilisin kexin type 9

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Cardiovascular Diabetology

ISSN: 1475-2840