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Table 2 Model performance

From: MR-proANP and incident cardiovascular disease in patients with type 2 diabetes with and without heart failure with preserved ejection fraction

  C-statistics Net reclassification index p-value
MR-proANP
 Continuous variable (univariable) 0.66 (0.61–0.71)   
 Cut-off 60 pmol/l (univariable) 0.57 (0.54–0.62)   
Multivariable analyses
 Model 1 0.72 (0.68–0.78)   
 Model 1 + MR-proANP (continuous) 0.74 (0.69–0.78) 27.1% (7.6–46.6) 0.007
 Model 1 + MR-proANP (Cut-off 60 pmol/l) 0.73 (0.68–0.77) 12.1% (-7.0–0.31) 0.22
Heart failure status
 Heart failure status (univariable) 0.63 (0.58–0.67)   
 Model 1 + heart failure status 0.75 (0.71–0.80) 32.8% (13.5–52.0)  < 0.001
  1. Model 1 includes age, sex, duration of diabetes, known CV disease, SBP > 170 mmHg, BMI and albuminuria
  2. The multivariable Cox proportional hazards model (Model 1) with NRI when adding MR-proANP as a continuous or dichomized variable or when adding heart failure status. For reference, the univariable Cox proportional hazards models with MR-proANP as a continuous or dichotomized variable, and with heart failure status are shown
  3. NRI, net reclassification index; MR-proANP, Mid-regional pro-atrial natriuretic peptide; CV, cardiovascular; SBP, systolic blood pressure; BMI, body mass index