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Table 2 Baseline characteristics by tertiles of systolic blood pressure

From: Blood pressure and mortality in patients with type 2 diabetes and a recent coronary event in the ELIXA trial

 

Tertile 1 n = 2008

SBP 74–124 mmHg

Tertile 2 n = 1909

SBP > 124–136 mmHg

Tertile 3 n = 1935

SBP > 136–225 mmHg

P

Age (years)

57.9 ± 9.8

60.5 ± 9.3

62.6 ± 9.3

 < 0.001

Female, n (%)

503 (25%)

603 (32%)

673 (35%)

 < 0.001

Race, n (%)

   

 < 0.001

 Asian

294 (15%)

274 (14%)

190 (10%)

 

 Black or African American

52 (3%)

74 (4%)

78 (4%)

 

 White

1444 (72%)

1447 (76%)

1517 (78%)

 

 Other

218 (11%)

114 (6%)

150 (8%)

 

Systolic blood pressure (mmHg)

114 ± 8

130 ± 4

149 ± 11

NA

Diastolic blood pressure (mmHg)

72 ± 7

79 ± 7

84 ± 9

 < 0.001

Pulse pressure (mmHg)

42 ± 7

51 ± 7

65 ± 12

NA

Heart rate (bpm)

71 ± 9

70 ± 9

70 ± 10

0.011

BMI (kg/m2)

29.1 ± 5.3

30.4 ± 5.8

31.0 ± 5.8

 < 0.001

Diabetes duration (years)

8.4 ± 8.0

9.2 ± 8.1

10.3 ± 9

 < 0.001

HbA1c (%)

7.7 ± 1.3

7.7 ± 1.3

7.7 ± 1.3

0.33

eGFR (ml/min/1.73m2)

78 ± 21

76 ± 21

74 ± 22

 < 0.001

Albuminuria (mg/g)

   

 < 0.001

 < 30 (normal)

1637 (82%)

1424 (75%)

1269 (66%)

 

 ≥ 30–< 300 (micro)

297 (15%)

363 (19%)

465 (24%)

 

 ≥ 300 (macro)

67 (3%)

117 (6%)

191 (10%)

 

BNP (pg/ml) median [IQR]

106 [49–234]

100 [47–203]

111 [54–226]

0.006

Smoking status, n (%)

   

 < 0.001

 Current

248 (12%)

214 (11%)

205 (11%)

 

 Former

1012 (50%)

789 (41%)

864 (45%)

 

 Never

748 (37%)

906 (48%)

866 (45%)

 

MI history other than index ACS, n (%)

402 (20%)

450 (24%)

489 (25%)

 < 0.001

Stroke history, n (%)

73 (4%)

106 (6%)

135 (7%)

 < 0.001

Heart failure history, n (%)

436 (22%)

469 (25%)

412 (21%)

0.030

Coronary revascularization history, n (%)

1449 (72%)

1241 (65%)

1391 (72%)

 < 0.001

STEMI at index event, n (%)

1088 (54%)

798 (42%)

687 (36%)

 < 0.001

Left ventricular ejection fractiona (percent)

48 ± 13

52 ± 12

52 ± 11

 < 0.001

Insulin, n (%)

733 (37%)

729 (38%)

819 (42%)

 < 0.001

Statin, n (%)

1889 (94%)

1755 (92%)

1788 (92%)

0.024

Beta blocker, n (%)

1691 (84%)

1597 (84%)

1665 (86%)

0.10

Calcium channel blocker, n (%)

224 (11%)

428 (22%)

629 (33%)

 < 0.001

Diuretic, n (%)

727 (36%)

728 (38%)

853 (44%)

 < 0.001

ACE inhibitor, n (%)

1233 (61%)

1164 (61%)

1135 (59%)

0.17

ARB, n (%)

418 (21%)

503 (26%)

634 (33%)

 < 0.001

Alpha blocker, n (%)

89 (4%)

67 (4%)

102 (5%)

0.029

Potassium sparing agents, n (%)

367 (18%)

268 (14%)

220 (11%)

 < 0.001

  1. Unless stated otherwise, values are mean ± SD or n (%)
  2. ACE angiotensin converting enzyme, ACS acute coronary syndrome, ARB angiotensin receptor blocker, BMI body mass index, BNP brain-type natriuretic peptide, eGFR estimated glomerular filtration rate, HbA1c glycosylated hemoglobin, HDL high density lipoprotein, LDL low density lipoprotein, MI myocardial infarction, SBP systolic blood pressure, STEMI ST segment elevation myocardial infarction
  3. aData available for 3957 patients for left ventricular ejection fraction (1424 in tertile 1, 1262 in tertile 2 and 1271 in tertile 3)