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Table 4 PCSK9 levels in relation to MACEs in patients with different diabetic status

From: Association of circulating PCSK9 concentration with cardiovascular metabolic markers and outcomes in stable coronary artery disease patients with or without diabetes: a prospective, observational cohort study

PCSK9 (ng/mL)

HR (95% CI)

Crude model

Model 1

Model 2

Non-DM

 PCSK9 per-SD increase

1.543 (1.224–1.945)b

1.571 (1.232–2.004)b

1.458 (1.128–1.885)b

 PCSK9 < 234.52 ng/mL

1.0 (Reference)

1.0 (Reference)

1.0 (Reference)

 PCSK9 ≥ 234.52 ng/mL

2.137 (1.210–3.775)b

2.140 (1.206–3.795)b

2.100 (1.174–3.757)a

DM

 PCSK9 per-SD increase

1.258 (0.975–1.623)

1.262 (0.972–1.639)

1.361 (1.037–1.785)a

 PCSK9 < 234.52 ng/mL

2.430 (1.264–4.467)b

2.424 (1.260–4.663)b

3.033 (1.442–6.376)b

 PCSK9 ≥ 234.52 ng/mL

4.092 (2.297–7.290)b

4.084 (2.274–7.333)b

5.233 (2.546–10.757)b

  1. MACEs major adverse cardiovascular events, non-DM diabetes mellitus, non-DM non-diabetes mellitus, CI confidence interval, HR hazard ratio, Model 1 adjusted for age and sex; Model 2 adjusted for model 1, body mass index, smoking, drinking, hypertension, family history of coronary artery disease, Gensini score, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hemoglobin A1c, fibrinogen and β-blockers
  2. afor p < 0.05
  3. bfor p < 0.01