Association of circulating PCSK9 concentration with cardiovascular metabolic markers and outcomes in stable coronary artery disease patients with or without diabetes: a prospective, observational cohort study

Table 3 Spearman correlation analysis between PCSK9 and cardiovascular metabolic makers

Variables	Overall		DM		Non-DM
	n = 1225		n = 377		n = 848
	r	p	r	p	r	p
Traditional lipid parameters
TC	0.199	< 0.0001	0.133	0.010	0.234	< 0.0001
TG	0.063	0.028	0.010	0.851	0.078	0.023
HDL-C	0.096	0.001	0.098	0.057	0.100	0.003
LDL-C	0.195	< 0.0001	0.153	0.003	0.215	< 0.0001
Novel lipid markers
non-HDL-C	0.180	< 0.0001	0.104	0.043	0.217	< 0.0001
Lp(a)	0.062	< 0.0001	0.079	0.126	0.054	0.117
ApoA1	0.092	0.001	0.104	0.044	0.090	0.009
ApoB	0.192	< 0.0001	0.138	0.007	0.213	< 0.0001
TRLP	0.045	0.116	0.046	0.371	0.038	0.264
Derived lipid indicators
TG/HDL-C	0.012	0.682	−0.032	0.538	0.023	0.510
LDL-C/HDL-C	0.073	0.010	0.026	0.620	0.089	0.009
TC/HDL-C	0.037	0.195	−0.019	0.712	0.056	0.102
ApoB/ApoA1	0.075	0.009	0.034	0.510	0.088	0.011
non-HDL-C/TC	0.037	0.195	−0.019	0.712	0.056	0.102
AIP	0.012	0.682	−0.032	0.538	0.023	0.510
LCI	0.112	< 0.0001	0.042	0.414	0.139	< 0.0001
Other metabolic indexes
SBP	−0.014	0.632	−0.001	0.988	−0.033	0.343
DBP	−0.039	0.169	−0.059	0.252	−0.035	0.315
BMI	−0.007	0.815	−0.042	0.417	−0.008	0.818
Glucose	0.104	< 0.0001	0.088	0.087	0.087	0.012
HbA_1C	0.123	< 0.0001	0.111	0.032	0.098	0.004
HGI	0.112	< 0.0001	0.076	0.141	0.085	0.013
TyG	0.088	0.002	0.040	0.435	0.087	0.011

PCSK9 proprotein convertase subtilisin/kexin type 9, CAD coronary artery disease, DM diabetes mellitus, non-DM non-diabetes mellitus, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, non-HDL-C non-high-density lipoprotein cholesterol, ApoA1 Apolipoprotein A1, ApoB apolipoprotein B, TRLP triglyceride-rich lipoproteins, AIP atherogenic index of plasma, LCI lipoprotein combine index, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, HbA_1C hemoglobin A_1C, HGI hemoglobin glycation index, TyG triglyceride glucose, p < 0.05 suggests significant difference. (TRLP = TC—HDL-C—LDL-C; LCI = TC ∗ TG ∗ LDL/HDL-C; AIP = log (TG/HDL-C); TyG = Ln (TG*FPG/2); HGI = observed HbA1c—predicted HbA1c), p < 0.05 suggests significant difference

ISSN: 1475-2840