Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Table 1 Effects of pitavastatin, pemafibrate or combination of pitavastatin and pemafibrate on BP, HR and blood measurements

Group	ND-vehicle	HD-vehicle	HD-pitavastatin	HD-pemafibrate	HD-combination
Food	ND	HD	HD	HD	HD
Treatment	Vehicle	Vehicle	Pitavastatin	Pemafibrate	Combination
Number of rats	5	9	10	10	10
SBP (mmHg)	143 ± 2	194 ± 7*	197 ± 8	193 ± 8	179 ± 10*#§†
HR (beats/min)	376 ± 11	402 ± 37	383 ± 19	400 ± 24	383 ± 31
Blood measurements
Total bilirubin (mg/dL)	0.01 ± 0.01	0.01 ± 0.01	0.03 ± 0.03	0.01 ± 0.01	0.02 ± 0.01
Glucose (mg/dL)	241 ± 20	236 ± 30	232 ± 22	236 ± 15	228 ± 15

Effects of pitavastatin, pemafibrate, or a combination of pitavastatin and pemafibrate on total and phospho-eNOS and NOX4 expression in the rat aorta
Values are mean ± SD. *P < 0.001 vs. ND-vehicle group. #P < 0.005 vs. HD-vehicle. §P < 0.001 vs. HD-pitavastatin group. †P < 0.01 vs. HD-pemafibrate group. ‡P < 0.005 vs. HD-vehicle
BP blood pressure, ND normal diet, HD high-salt and high-fat diet, SBP systolic blood pressure, HR heart rate

ISSN: 1475-2840