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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Fig. 5

Effects of pitavastatin, pemafibrate, or combination of pitavastatin and pemafibrate on total and phospho-eNOS and NOX4 expression in the rat aorta. a Images of Western blot analysis of total and phospho-endothelial nitric oxide synthase (eNOS) in aorta from rats fed a high-salt and high-fat diet (HD). b Western blot analysis of total eNOS. c Western blot analysis of phospho-eNOS. d qPCR analysis of NOX4 mRNA. Data are presented relative to ND-vehicle and expressed as the mean ± SD. Number of rats in each group: ND-vehicle, n = 4; HD-vehicle, n = 6; HD-pitavastatin, n = 6; HD-pemafibrate, n = 6; and HD-combination, n = 6. Statistical analysis was performed using a one-way ANOVA with a Bonferroni post hoc test

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Cardiovascular Diabetology

ISSN: 1475-2840