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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet

Fig. 2

Effects of pitavastatin, pemafibrate, or a combination of pitavastatin and pemafibrate on plasma cholesterol profile. Rats were fed a normal diet (ND) or a high-salt and high-fat diet (HD). The rats were divided into five groups and treated with vehicle, pitavastatin, pemafibrate (K-877), or a combination of pitavastatin and pemafibrate. a Total cholesterol, b chylomicron (CM)-cholesterol, c very low-density lipoprotein (VLDL)-cholesterol, d low-density lipoprotein (LDL)-cholesterol, e high-density lipoprotein (HDL)-cholesterol. Data are expressed as the mean ± SD. Number of rats in each group: ND-vehicle, n = 5; HD-vehicle, n = 9; HD-pitavastatin, n = 10; HD-pemafibrate, n = 10; and HD-combination, n = 10. Statistical analysis was performed using a one-way ANOVA with a Bonferroni post hoc test

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Cardiovascular Diabetology

ISSN: 1475-2840