Table 3 Multivariable-adjusted hazard ratios of incident CHD according to the 1-SD increase in TyG-index, stratified by genders: Tehran Lipid and Glucose Study

TyG-index

1.16 (1.05–1.29)

0.005

1.23 (1.07–1.39)

0.003

1.19 (1.10–1.29)

< 0.001

Age (years)

1.05 (1.04–1.06)

< 0.001

1.04 (1.03–1.05)

< 0.001

1.05 (1.04–1.05)

< 0.001

WC (cm)

1.02 (1.00–1.04)

0.036

1.02 (1.00–1.03)

0.066

1.02 (1.01–1.03)

0.004

BMI (kg/m²)

0.96 (0.92–1.01)

0.100

0.97 (0.94–1.01)

0.162

0.97 (0.94–1.00)

0.020

Education (years)

 < 6

Reference

Reference

Reference

 6–12

1.21 (0.98-1.49)

0.075

0.81 (0.60–1.09)

0.161

1.04 (0.88–1.23)

0.629

 ≥ 12

1.02 (0.76-1.36)

0.904

0.57 (0.27–1.17)

0.122

0.88 (0.68–1.15)

0.343

Smoking

Never

Reference

Reference

Reference

Past

1.39 (1.11–1.75)

0.004

1.08 (0.65–1.80)

0.768

1.34 (1.09–1.64)

0.005

Current

1.67 (1.37–2.04)

< 0.001

1.68 (1.08–2.59)

0.020

1.68 (1.41–2.01)

< 0.001

Low physical activity

1.09 (0.90–1.32)

0.382

1.06 (0.84–1.33)

0.650

1.08 (0.93–1.25)

0.325

FH-CVD

1.39 (1.10–1.74)

0.005

1.63 (1.30–2.06)

< 0.001

1.51 (1.28–1.77)

< 0.001

T2D

1.53 (1.20–1.95)

0.001

2.01 (1.54–2.61)

< 0.001

1.74 (1.46–2.08)

< 0.001

Hypertension

1.45 (1.19–1.76)

< 0.001

1.73 (1.37–2.17)

< 0.001

1.57 (1.35–1.81)

< 0.001

Lipid drug

0.91 (0.56–1.48)

0.696

1.24 (0.91–1.69)

0.171

1.12 (0.87–1.45)

0.380

LDL-C (mmol/L)

1.37 (1.25–1.50)

< 0.001

1.21 (1.09–1.33)

< 0.001

1.30 (1.22–1.39)

< 0.001

HDL-C (mmol/L)

0.71 (0.48–1.06)

0.097

0.69 (0.46–1.03)

0.072

0.72 (0.54–0.96)

0.023

Gender (female)

–

–

–

–

0.60 (0.50–0.71)

< 0.001