Visit-to-visit fasting plasma glucose variability is associated with left ventricular adverse remodeling in diabetic patients with STEMI

Table 3 Multivariate regression analysis for LVAR after STEMI

	Model 1		Model 2		Model 3		Model 4
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
CV		0.026*		0.031*		0.015*		0.035*
T1	Reference	–	Reference	–	Reference	–	Reference	–
T2	1.080 (0.586–2.000)	0.804	1.048 (0.444–2.496)	0.915	1.116 (0.457–2.757)	0.810	1.049 (0.412–2.682)	0.920
T3	1.879 (1.067–3.364)	0.031	2.652 (1.110–6.551)	0.030	3.333 (1.301–8.953)	0.014	3.021 (1.081–8.764)	0.037
SD		0.005*		0.012*		0.005*		0.013*
T1	Reference	–	Reference	–	Reference	–	Reference	–
T2	1.202 (0.645–2.255)	0.563	0.835 (0.341–2.032)	0.689	0.846 (0.336–2.125)	0.721	0.830 (0.313–2.184)	0.705
T3	2.265 (1.279–4.100)	0.006	3.063 (1.277–7.613)	0.013	3.963 (1.541–10.667)	0.005	3.832 (1.307–11.658)	0.016
VIM		0.364*		0.060*		0.017*		0.012*
T1	Reference	–	Reference	–	Reference	–	Reference	–
T2	1.664 (0.935–3.002)	0.086	2.877 (1.289–6.860)	0.012	3.499 (1.500–8.736)	0.005	3.314 (1.403–8.344)	0.008
T3	1.333 (0.735–2.438)	0.345	2.379 (0.998–5.932)	0.055	3.196 (1.273–8.475)	0.016	3.404 (1.342–9.142)	0.012

Model 1, includes adjustment for age and sex
Model 2, additional adjustment for history of hypertension, duration of diabetes, smoking status, baseline HbA1c, postprandial plasma glucose, non-HDL cholesterol, eGFR, the presence of multivessel disease, peak value of troponin I and baseline LVEF
Model 3, additional adjustment for medication use of oral hypoglycemic agents, insulin, beta blocker and ACEI/ARB
Model 4, additional adjustment for mean FPG level during follow-up
* P for trend. ACEI angiotensin-converting enzyme inhibitor; ARB angiotensin receptor blocker, CI confidence interval, CV coefficient of variation, eGFR estimated glomerular filtration rate, FPG fasting plasma glucose, HbA1c glycated hemoglobin A1c, HDL high-density lipoprotein, LVAR left ventricular adverse remodeling, LVEF left ventricular ejection fraction, OR odds ratio, SD standard deviation, STEMI ST-segment elevation myocardial infarction, VIM variability independent of the mean

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