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Table 3 Multivariate analysis

From: Visit-to-visit HbA1c variability is associated with in-stent restenosis in patients with type 2 diabetes after percutaneous coronary intervention

Tertiles

Model 1

Model 2

Model 3

Model 4

Model 5

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

CV

 

0.004*

 

0.008*

 

0.015*

 

0.013*

 

0.023*

T1

Reference

–

Reference

–

Reference

–

Reference

–

Reference

–

T2

1.22 (0.45–3.27)

0.698

1.03 (0.38–2.79)

0.958

0.96 (0.34–2.74)

0.946

1.00 (0.35–2.86)

1.000

0.97 (0.34–2.75)

0.950

T3

3.26 (1.37–7.76)

0.008

3.06 (1.26–7.45)

0.014

2.92 (1.18–7.20)

0.020

3.28 (1.25–8.55)

0.015

3.00 (1.14–7.92)

0.026

SD

 

0.002*

 

0.004*

 

0.008*

 

0.006*

 

0.013*

T1

Reference

–

Reference

–

Reference

–

Reference

–

Reference

–

T2

1.60 (0.58–4.40)

0.364

1.27 (0.45–3.59)

0.648

1.11 (0.38–3.20)

0.848

1.21 (0.41–3.55)

0.727

1.15 (0.40–3.37)

0.792

T3

3.88 (1.54–9.77)

0.004

3.53 (1.38–9.06)

0.009

3.28 (1.25–8.65)

0.016

4.02 (1.39–11.61)

0.010

3.69 (1.23–11.05)

0.020

VIM

 

0.020*

 

0.042*

 

0.029*

 

0.030*

 

0.032*

T1

Reference

–

Reference

–

Reference

–

Reference

–

Reference

–

T2

1.85 (0.73–4.70)

0.196

1.78 (0.69–4.54)

0.230

1.74 (0.66–4.58)

0.265

1.74 (0.66–4.60)

0.267

1.67 (0.63–4.43)

0.304

T3

2.82 (1.16–6.85)

0.022

2.53 (1.02–6.26)

0.045

2.86 (1.11–7.38)

0.030

2.86 (1.10–7.42)

0.031

2.82 (1.09–7.29)

0.032

  1. Model 1, includes adjustment for age and sex; Model 2: additional adjustment for systolic and diastolic blood pressure, body mass index, non-HDL cholesterol and eGFR; Model 3, additional adjustment for the post-PCI reference diameter of target vessel, total stented length and medication use including oral hypoglycemic agent and insulin; Model 4, model 3 with additional adjustment for baseline HbA1c; Model 5, model 3 with additional adjustment for the mean HbA1c during follow-up. * P for trend
  2. CI confidence interval, CV coefficient of variation, eGFR estimated glomerular filtration rate, HbA1c glycated hemoglobin A1c, HDL high-density lipoprotein, HR hazard ratios, PCI percutaneous coronary intervention, SD standard deviation, VIM variability independent of the mean