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Table 1 Clinical and biological characteristics according to the TyG tertiles

From: Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes

  Lowest tertile (7.80–9.37) (n = 56) Mid tertile (9.38–9.99) (n = 55) Highest tertile (10.00–10.96) (n = 55) p value
Age (years) 58.5 ± 10.1 60.6 ± 11.4 57.5 ± 11.0 0.306
Gender (M/F) 36/20 34/21 33/22 0.897
BMI (kg/m2) 23.6 ± 2.8 25.0 ± 2.5 25.8 ± 2.1  < 0.001
Waist circumference (cm) 86.0 ± 11.7 91.2 ± 10.9 94.0 ± 9.9 0.001
Male 90.2 ± 11.9 94.9 ± 9.9 96.4 ± 9.1 0.041
Female 78.4 ± 6.1 85.2 ± 10.2 90.4 ± 10.2  < 0.001
Systolic blood pressure (mmHg) 138.9 ± 21.3 139.2 ± 22.9 143.7 ± 23.1 0.456
Diastolic blood pressure (mmHg) 85.9 ± 13.4 85.4 ± 14.1 85.6 ± 14.0 0.975
Duration of diabetes (years) 4 [3–6] 4 [3–8] 7 [3–12] 0.044
Practicing physical activity 24 (42.9%) 12 (21.8%) 7 (12.7%) 0.001
Smoking 15 (26.8%) 22 (40%) 24 (43.6%) 0.152
Metabolic syndrome 23 (41.1%) 42 (76.4%) 44 (80.0%)  < 0.001
Total cholesterol (mg/dL) 207.1 ± 46.3 224.1 ± 55.2 232.8 ± 52.7 0.03
Triglycerides (mg/dL) 146.9 ± 42.2 209.9 ± 44.2 330.8 ± 70.4  < 0.001
HDL-cholesterol (mg/dL) 50.0 ± 12.4 41.9 ± 8.2 40.1 ± 7.8  < 0.001
LDL-cholesterol (mg/dL) 126.1 ± 36.7 130.4 ± 44.0 146.0 ± 51.5 0.042
Non-HDL cholesterol (mg/dl) 157.1 ± 43.3 182.2 ± 54.6 192.7 ± 51.5  < 0.001
Fasting plasma glucose (mg/dL) 111.9 ± 27.7 159.7 ± 29.3 189.0 ± 43.2  < 0.001
HbA1c (%) 7.3 ± 0.6 8.0 ± 0.9 8.3 ± 1.0  < 0.001
TyG index 8.95 ± 0.37 9.67 ± 0.19 10.33 ± 0.23  < 0.001
Insulin (mU/L) 17 [12–28] 30 [18–39] 30 [18–39]  < 0.001
HOMA-IR index 4.45 [2.85–6.88] 10.20 [6.40–14.30] 12.40 [8.30–16.60]  < 0.0001
eGFR (mL/min/1.73 m2) 89.4 ± 28.1 82.2 ± 21.0 84.0 ± 20.3 0.239
Coronary artery stenosis ≥ 50% (%) 16 (28.6) 16 (29.1) 28 (50.9) 0.021
Coronary artery stenosis ≥ 70% (%) 5 (8.9) 11 (20.0) 16 (29.1) 0.026
Drug therapy
 Metformin 55 (98.2%) 53 (96.4%) 55 (100%) 0.359
 Sulphonylurea 50 (89.3%) 51 (92.7%) 48 (87.3%) 0.634
 Thiazolidinedione 1 (1.8%) 0 (0%) 0 (0%) 0.372
 DPP-4 inhibitors 1 (1.8%) 1 (1.8%) 3 (5.5%) 0.432
 α-glucosidase inhibitor 4 (7.1%) 12 (21.8%) 14 (25.5%) 0.029
 Insulin 2 (3.6%) 0 (0%) 1 (1.8%) 0.369
 Antiplatelet 30 (53.6%) 32 (58.2%) 32 (58.2%) 0.852
 Statin 33 (58.9%) 32 (58.2%) 31 (56.4%) 0.961
  1. Data are expressed as mean ± SD, median (interquartile range) or number (%)
  2. Comparisons were performed using ANOVA or Kruskall-Wallis tests and chi square tests
  3. BMI body mass index, M/F male/female, eGFR estimated glomerular filtration rate, HOMA-IR homeostatic model assessment of insulin resistance, TyG triglyceride glucose index