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Table 7 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in ER stress pathway

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNAs Up/downregulation (Obesity) Refs. Function Refs. Target Refs.
miR-30d Up [58] Unknown GRP78/BIP [288]
miR-181a Up [225, 226] Oxidative stress-induced EC dysfunction [224] GRP78/BIP [288]
miR-199a Up [184, 188] EC dysfunction [185] GRP78/BIP [288]
miR-204 Up [44] EC dysfunction [44] PERK [289, 290]
miR-214 Up [294, 295] Regulates EC function [294, 295] ATF 4, XBP1 [293, 307]
miR-663 Up [297] Regulates oscillatory shear in EC- atherosclerosis [297] ATF 4 [296]
miR-211 Up [301] Promotes atherosclerosis [302] CHOP [300]
miR-1291 Unknown EC dysfunction [305, 306] UPR, IRE1α [303]
miR30c Down [268, 269] EC inflammation [268, 269] XBP1 [308]
miR-24 Up [58,59,60] Exacerbates atherogenesis and plaque formation [62, 63] PERK&IRE1 [309]
miR-23a Up [261] Promotes atherosclerotic plaque formation [260] PERK&IRE1 [309]
miR-27a Up [310] Atherosclerosis formation [311] PERK&IRE1 [309]
miR-221 Up [313] EC dysfunction [314] ATF6 [312]
miR-145 Up [315] Promotes atherosclerosis [317] ATF6 [312]
miR-494 Up [316] Promotes atherosclerosis [318, 319] ATF6 [312]