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Table 6 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy fusion and degradation machinery

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNAs Up/downregulation (Obesity) Refs. Function Refs. Target Refs.
miR-374 Up [228] Deregulating vascular endothelial growth factor receptor-1 signaling [229] UVRAG [227]
miR-630 Up [231] Suppresses autophagy [231] UVRAG [227]
miR-125 Up [255, 256] EC senescence and atherosclerosis [255, 256] UVRAG [254]
miR-351 Up [257] Attenuate EC survival [257] UVRAG [254]
miR-23a Up [261] Promotes atherosclerotic plaque formation [260] Lamp1 [258]
miR-320a Up [262] Regulates atherogenesis [263] Lamp1 [259]
miR-487-5p Up [140] Unknown Lamp2 [264]
miR30c Down [268, 269] EC inflammation [268, 269] Rab7 [267]
miR-96 Up [241] EC impairment [274] VAMP8 [271]
miR-124 Up [273] EC apoptosis [275] STX17 [272]