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Table 6 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy fusion and degradation machinery

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNAs

Up/downregulation (Obesity)

Refs.

Function

Refs.

Target

Refs.

miR-374

Up

[228]

Deregulating vascular endothelial growth factor receptor-1 signaling

[229]

UVRAG

[227]

miR-630

Up

[231]

Suppresses autophagy

[231]

UVRAG

[227]

miR-125

Up

[255, 256]

EC senescence and atherosclerosis

[255, 256]

UVRAG

[254]

miR-351

Up

[257]

Attenuate EC survival

[257]

UVRAG

[254]

miR-23a

Up

[261]

Promotes atherosclerotic plaque formation

[260]

Lamp1

[258]

miR-320a

Up

[262]

Regulates atherogenesis

[263]

Lamp1

[259]

miR-487-5p

Up

[140]

Unknown

Lamp2

[264]

miR30c

Down

[268, 269]

EC inflammation

[268, 269]

Rab7

[267]

miR-96

Up

[241]

EC impairment

[274]

VAMP8

[271]

miR-124

Up

[273]

EC apoptosis

[275]

STX17

[272]