From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
miRNAs | Up/downregulation (Obesity) | Refs. | Function | Refs. | Target | Refs. |
---|---|---|---|---|---|---|
miR-374 | Up | [228] | Deregulating vascular endothelial growth factor receptor-1 signaling | [229] | UVRAG | [227] |
miR-630 | Up | [231] | Suppresses autophagy | [231] | UVRAG | [227] |
miR-125 | Up | EC senescence and atherosclerosis | UVRAG | [254] | ||
miR-351 | Up | [257] | Attenuate EC survival | [257] | UVRAG | [254] |
miR-23a | Up | [261] | Promotes atherosclerotic plaque formation | [260] | Lamp1 | [258] |
miR-320a | Up | [262] | Regulates atherogenesis | [263] | Lamp1 | [259] |
miR-487-5p | Up | [140] | Unknown | – | Lamp2 | [264] |
miR30c | Down | EC inflammation | Rab7 | [267] | ||
miR-96 | Up | [241] | EC impairment | [274] | VAMP8 | [271] |
miR-124 | Up | [273] | EC apoptosis | [275] | STX17 | [272] |