From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
miRNA | Up/downregulation (Obesity) | Refs. | Function | Refs. | Target | Refs. |
---|---|---|---|---|---|---|
miR-181a | Up | Oxidative stress-induced EC dysfunction and atherosclerosis | [224] | ATG5 | [223] | |
miR-374a | Up | [228] | Negatively regulates vascular endothelial growth factor receptor-1 signaling | [229] | ATG5 | [227] |
miR-30d | Up | [58] | Unknown | – | ATG12 | [230] |
miR-630 | Up | [231] | Suppresses autophagy | [231] | ATG12 | [230] |
miR-210 | Up | [125] | EC apoptosis and atherosclerosis | [125] | ATG7 | [233] |
miR-188-3p | Unknown | – | Induction of atherosclerosis | [236] | ATG7 | [234] |
miR-137 | Up | [237] | EC dysfunction | [238] | ATG7 | [235] |
miR-20a | Up | [17] | EC dysfunction | [203] | ATG16L1 | [239] |
miR-96 | Up | [241] | EC dysfunction | [242] | ATG16L1 | [240] |
miR-204 | Up | [44] | EC dysfunction | [ [44] | LC3 | [243] |
miR-17 | Up | [206] | Triggers a switch of EC to an angiogenic phenotype | [245] | P62 | [244] |
miR-93 | Up | [246] | Regulates EC glycolysis and proliferation | P62 | [244] | |
miR-20a | Up | [17] | Regulates EC migration, angiogenesis and senescence | [203] | P62 | [244] |
miR-20b | Up | [209] | Promotes EC senescence | [210] | P62 | [244] |
miR-106 | Up | [204] | EC proliferation and atherosclerosis | [205] | P62 | [244] |