Skip to main content

Table 5 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy elongation and nucleation machinery

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA

Up/downregulation (Obesity)

Refs.

Function

Refs.

Target

Refs.

miR-181a

Up

[225, 226]

Oxidative stress-induced EC dysfunction and atherosclerosis

[224]

ATG5

[223]

miR-374a

Up

[228]

Negatively regulates vascular endothelial growth factor receptor-1 signaling

[229]

ATG5

[227]

miR-30d

Up

[58]

Unknown

ATG12

[230]

miR-630

Up

[231]

Suppresses autophagy

[231]

ATG12

[230]

miR-210

Up

[125]

EC apoptosis and atherosclerosis

[125]

ATG7

[233]

miR-188-3p

Unknown

Induction of atherosclerosis

[236]

ATG7

[234]

miR-137

Up

[237]

EC dysfunction

[238]

ATG7

[235]

miR-20a

Up

[17]

EC dysfunction

[203]

ATG16L1

[239]

miR-96

Up

[241]

EC dysfunction

[242]

ATG16L1

[240]

miR-204

Up

[44]

EC dysfunction

[ [44]

LC3

[243]

miR-17

Up

[206]

Triggers a switch of EC to an angiogenic phenotype

[245]

P62

[244]

miR-93

Up

[246]

Regulates EC glycolysis and proliferation

[239, 247, 248]

P62

[244]

miR-20a

Up

[17]

Regulates EC migration, angiogenesis and senescence

[203]

P62

[244]

miR-20b

Up

[209]

Promotes EC senescence

[210]

P62

[244]

miR-106

Up

[204]

EC proliferation and atherosclerosis

[205]

P62

[244]