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Table 5 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy elongation and nucleation machinery

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA Up/downregulation (Obesity) Refs. Function Refs. Target Refs.
miR-181a Up [225, 226] Oxidative stress-induced EC dysfunction and atherosclerosis [224] ATG5 [223]
miR-374a Up [228] Negatively regulates vascular endothelial growth factor receptor-1 signaling [229] ATG5 [227]
miR-30d Up [58] Unknown ATG12 [230]
miR-630 Up [231] Suppresses autophagy [231] ATG12 [230]
miR-210 Up [125] EC apoptosis and atherosclerosis [125] ATG7 [233]
miR-188-3p Unknown Induction of atherosclerosis [236] ATG7 [234]
miR-137 Up [237] EC dysfunction [238] ATG7 [235]
miR-20a Up [17] EC dysfunction [203] ATG16L1 [239]
miR-96 Up [241] EC dysfunction [242] ATG16L1 [240]
miR-204 Up [44] EC dysfunction [ [44] LC3 [243]
miR-17 Up [206] Triggers a switch of EC to an angiogenic phenotype [245] P62 [244]
miR-93 Up [246] Regulates EC glycolysis and proliferation [239, 247, 248] P62 [244]
miR-20a Up [17] Regulates EC migration, angiogenesis and senescence [203] P62 [244]
miR-20b Up [209] Promotes EC senescence [210] P62 [244]
miR-106 Up [204] EC proliferation and atherosclerosis [205] P62 [244]