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Table 4 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy induction machinery

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA Up/downregulation (Obesity) Refs. Function Refs. Target Refs.
miR-155 Up [65] EC dysfunction [183] mTOR [178, 181]
miR-199a Up [184, 188] EC dysfunction [185] mTOR, ULK1 [178, 180, 182, 185]
miR-101 Up [186, 188] EC dysfunction [187] mTOR [178, 179]
miR-451 Up [193] Cardiac hypertrophy [193] AMPK [193, 195]
miR-148b Up [194] Hyperglycemia-induced EC dysfunction [155] AMPK [192]
miR-20a Up [143] Regulates EC migration, angiogenesis and senescence [203, 211] ULK1, FIP200 [199, 208]
miR-20b Up [209] Promotes EC senescence [210, 211] FIP200 [208]
miR-106b Up [204] EC proliferation and atherosclerosis [205] ULK1 [199, 201]
miR-17-5p Up [206] ECs apoptosis and cardiac dysfunction [207] ULK1 [202]
miR-506-3p Unknown Aggravates injury in vascular EC [212] Beclin 1 [ [212]
miR-216a Unknown Controls ox-LDL induced autophagy [216] Beclin 1 [216]
miR-129-5p Up [218] Alters EC autophagy [218] Beclin 1 [218]
miR-376b Up [219] Autophagy impairment, EC dysfunction [155, 220] Beclin 1 [220]