Table 4 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy induction machinery

miR-155

Up

[65]

EC dysfunction

[183]

mTOR

[178, 181]

miR-199a

Up

[184, 188]

EC dysfunction

[185]

mTOR, ULK1

[178, 180, 182, 185]

miR-101

Up

[186, 188]

EC dysfunction

[187]

mTOR

[178, 179]

miR-451

Up

[193]

Cardiac hypertrophy

[193]

AMPK

[193, 195]

miR-148b

Up

[194]

Hyperglycemia-induced EC dysfunction

[155]

AMPK

[192]

miR-20a

Up

[143]

Regulates EC migration, angiogenesis and senescence

[203, 211]

ULK1, FIP200

[199, 208]

miR-20b

Up

[209]

Promotes EC senescence

[210, 211]

FIP200

[208]

miR-106b

Up

[204]

EC proliferation and atherosclerosis

[205]

ULK1

[199, 201]

miR-17-5p

Up

[206]

ECs apoptosis and cardiac dysfunction

[207]

ULK1

[202]

miR-506-3p

Unknown

–

Aggravates injury in vascular EC

[212]

Beclin 1

[ [212]

miR-216a

Unknown

–

Controls ox-LDL induced autophagy

[216]

Beclin 1

[216]

miR-129-5p

Up

[218]

Alters EC autophagy

[218]

Beclin 1

[218]

miR-376b

Up

[219]

Autophagy impairment, EC dysfunction

[155, 220]

Beclin 1

[220]