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Table 3 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in the redox system

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA Up/downregulation (obesity) Refs. Function Refs. Target Refs.
miR-210 Unknown EC apoptosis and atherosclerosis [125] ISCU 1,2 [124]
miR-21 Up [130, 131] Promotes ROS production [132, 133] SOD [132, 133]
miR-551b Up [ [140] Enhances ROS accumulation [134, 135] CAT, SOD [134, 135]
miR-200c Up [142, 143] EC apoptosis, ROS accumulation and senescence [144, 145] PRDX2 [144]
miR-17 Up [151, 152] EC dysfunction [151, 152] SOD, Gpx2 [149]
miR-23b Up [148] EC dysfunction [52, 146] PRDX3 [147]
miR-29 Up [154] EC dysfunction, Cellular senescence [155, 156] ROS [153]
miR-448 Down [162, 163] Attenuation of NOX2 induced-ROS accumulation [161] NOX2 [161]
miR-19b Down [166] Attenuation of inflammation-induced EC apoptosis [165] p47phox [164]
miR-25 Down [170] Prevent ROS production [170] NOX4 [170]
miR-146a Up [174] EC inflammation [173] NOX4 [173]