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Table 1 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in endothelial cells (eNOS)

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA

Up/downregulation (obesity)

Refs.

Function

Refs.

Target

Refs.

miR-24

Up

[58,59,60]

Exacerbates atherogenesis and plaque formation

[62, 63]

eNOS

[54,55,56,57]

miR-155

Up

[65, 66]

Adipocytes hypertrophy and inflammation

[65]

eNOS

[64]

miR-15b

Up

[71, 72]

Hepatic insulin resistance

[71]

eNOS

[70]

miR-16

Up

[71, 72]

Increases inflammation

[73]

eNOS

[70]

miR-221/222

Up

[75]

Increases atherosclerosis

[75]

eNOS

[75]

miR-765

Unknown

–

Coronary artery disease

[78]

eNOS

[76, 77]