From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
miRNA | Up/downregulation (obesity) | Refs. | Function | Refs. | Target | Refs. |
---|---|---|---|---|---|---|
miR-24 | Up | Exacerbates atherogenesis and plaque formation | eNOS | |||
miR-155 | Up | Adipocytes hypertrophy and inflammation | [65] | eNOS | [64] | |
miR-15b | Up | Hepatic insulin resistance | [71] | eNOS | [70] | |
miR-16 | Up | Increases inflammation | [73] | eNOS | [70] | |
miR-221/222 | Up | [75] | Increases atherosclerosis | [75] | eNOS | [75] |
miR-765 | Unknown | – | Coronary artery disease | [78] | eNOS |