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Table 1 MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in endothelial cells (eNOS)

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

miRNA Up/downregulation (obesity) Refs. Function Refs. Target Refs.
miR-24 Up [58,59,60] Exacerbates atherogenesis and plaque formation [62, 63] eNOS [54,55,56,57]
miR-155 Up [65, 66] Adipocytes hypertrophy and inflammation [65] eNOS [64]
miR-15b Up [71, 72] Hepatic insulin resistance [71] eNOS [70]
miR-16 Up [71, 72] Increases inflammation [73] eNOS [70]
miR-221/222 Up [75] Increases atherosclerosis [75] eNOS [75]
miR-765 Unknown Coronary artery disease [78] eNOS [76, 77]