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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

Fig. 2

Obesity induces endothelial dysfunction. Obesity induces a decrease in NO bioavailability by: reducing eNOS activation and/or expression; negatively regulating SIRT1; and inducing cellular stresses including oxidative stress, ER stress and autophagy disruption. All of these effects lead to endothelial dysfunction. NO: Nitric Oxide; eNOS: endothelial Nitric Oxide Synthase; SIRT1: Sirtuin 1; ER: endoplasmic reticulum

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