| Low CV risk | Midpoint CV risk | High CV risk | |||
---|---|---|---|---|---|---|
CV risk score: –2.53 | CV risk score: –1.39 | CV risk score: –0.25 | ||||
NNT: 380 | NNT: 159 | NNT: 117 | ||||
Subject profile | A | B | C | D | E | F |
Hazard ratio (semaglutide vs comparators) | 0.45 | 0.45 | 0.62 | 0.62 | 0.84 | 0.84 |
Age, years | 48 | 46 | 66 | 67 | 64 | 71 |
HbA1c, % | 8.6 | 7.0 | 7.2 | 10.3 | 9.6 | 9.4 |
Smoking status, current/previous/never | Never | Never | Previous | Never | Previous | Never |
LDL-C, mmol/L | 3.3 | 3.3 | 3.2 | 3.9 | 4.5 | 5.2 |
Pulse rate, bpm | 76 | 80 | 76 | 67 | 66 | 88 |
Systolic BP, mmHg | 119 | 138 | 137 | 163 | 133 | 180 |
Prior ischemic heart disease, yes/no | No | No | No | No | No | Yes |
Prior MI, yes/no | No | No | No | No | No | No |
Prior stroke, yes/no | No | No | No | No | Yes | No |
HF, NYHA class | No HF | No HF | No HF | No HF | Othera | II |
Insulin use, yes/no | No | No | No | No | Yes | No |
eGFR, ml/min/1.73 m2 | 117.7 | 116.2 | 91.7 | 94.1 | 88.9 | 66.9 |