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Table 1 Clinical and biochemical parameters for control subjects and diabetic patients, according to quartile of ANGPTL8 levels

From: Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

Characteristics Control (ANGPTL8, pg/mL) p value Diabetes (ANGPTL8, pg/mL) p value
Q1 (< 372.15) Q2 (372.15–537.58) Q3 (537.59–74.09) Q4 (> 746.09) Q1 (< 347.15) Q2 (347.15–534.23) Q3 (534.24–810.50) Q4 (> 810.50)
N 192 193 192 192   192 193 192 192  
ANGPTL8 (pg/ml) 261.28 (188.24–317.25) 432.03 (403.26–476.68) 623.40 (573.62–690.53) 959.43 (850.77–1143.01)  < 0.001 256.45 (189.45–300.93) 462.97 (406.66–496.93) 642.52 (586.97–729.70) 1009.54 (893.07–1268.33)  < 0.001
Age (years) 54.44 \(\pm\) 9.03 56.97 \(\pm\) 8.75 59.54 \(\pm\) 8.91 64.87 \(\pm\) 9.82  < 0.001 59.14 \(\pm\) 9.56 58.30 \(\pm\) 9.37 61.33 \(\pm\) 9.21 63.57 \(\pm\) 9.16  < 0.001
Male (%) 47 (24.5) 59 (30.6) 68 (35.4) 92 (47.9)  < 0.001 40 (20.8) 59 (30.6) 68 (35.4) 99 (51.6)  < 0.001
BMI (kg/m2) 23.39 \(\pm\) 3.16 23.05 \(\pm\) 3.03 23.35 \(\pm\) 2.93 23.71 \(\pm\) 3.21 0.24 24.37 \(\pm\) 3.50 24.79 \(\pm\) 3.44 24.10 \(\pm\) 3.23 23.62 \(\pm\) 3.67 0.009
WHR 0.84 (0.80–0.88) 0.85 (0.81–0.89) 0.85 (0.81–0.90) 0.87 (0.83–0.90) 0.005 0.88 (0.85–0.91) 0.88 (0.84–0.93) 0.88 (0.84–0.92) 0.88 (0.84–0.91) 0.53
SBP 139 (127–156) 145 (129–162) 146 (130–164) 151 (135–168)  < 0.001 150 (136–168) 149 (135–166) 155 (138–173) 154 (137–173) 0.33
HbA1c (%) 5.50 (5.30–5.80) 5.50 (5.30–5.70) 5.60 (5.40–5.80) 5.60 (5.40–5.90) 0.003 6.50 (5.80–7.70) 6.50 (5.85–8.15) 6.55 (5.90–8.15) 6.40 (5.73–7.80) 0.62
FPG (mmol/L) 5.04 (4.75–5.34) 5.02 (4.77–5.28) 5.00 (4.72–5.26) 5.06 (4.80–5.31) 0.39 7.18 (5.95–8.13) 7.26 (6.19–9.02) 7.37 (6.05–8.98) 7.35 (5.98–8.66) 0.38
2 h PG (mmol/L) 5.72 (4.92–6.42) 5.83 (5.01–6.56) 5.72 (4.91–6.44) 5.84 (5.20–6.63) 0.18 11.38 (7.93–13.72) 12.17 (7.77–15.70) 12.12 (8.31–14.38) 12.06 (9.24–15.74) 0.09
Fasting insulin (pmol/mL) 5.00 (3.50–7.08) 4.80 (3.20–6.90) 4.80 (3.40–7.10) 4.80 (3.40–7.00) 0.58 6.80 (4.30–12.50) 7.10 (4.25–10.95) 6.85 (4.40–10.45) 6.15 (3.63–11.18) 0.48
HOMA-IR 1.19 (0.77–1.62) 1.09 (0.70–1.52) 1.06 (0.74–1.59) 1.06 (0.77–1.59) 0.72 2.24 (1.41–4.04) 2.39 (1.33–4.13) 2.42 (1.34–3.98) 2.17 (1.15–4.00) 0.59
HOMA-\(\beta\)(%) 66.221 (45.56–89.32) 61.76 (44.59–91.01) 70.91 (44.32–100.00) 59.98 (42.72–84.54) 0.20 41.76 (23.60–73.88) 38.76 (18.13–73.84) 36.27 (22.39–63.55) 36.14(17.70–65.55) 0.31
Fasting HDL (mmol/L) 1.37 (1.14–1.60) 1.38 (1.17–1.60) 1.36 (1.15–1.61) 1.34 (1.13–1.61) 0.94 1.44 (1.24–1.70) 1.35 (1.17–1.61) 1.35 (1.16–1.58) 1.32 (1.11–1.62) 0.03
Fasting LDL (mmol/L) 2.43 (2.06–2.96) 2.58 (2.11–3.06) 2.59 (2.10–3.06) 2.62 (2.17–3.04) 0.25 2.93 (2.37–3.64) 2.97 (2.36–3.54) 3.03 (2.42–3.61) 2.83 (2.25–3.50) 0.20
Fasting TG (mmol/L) 1.19 (0.87–1.63) 1.18 (0.90–1.73) 1.16 (0.86–1.74) 1.23 (0.89–1.74) 0.45 1.46 (1.04–2.17) 1.46 (0.95–2.10) 1.49 (1.07–2.08) 1.49 (1.00–2.55) 0.67
Cholesterol (mmol/L) 4.58 (3.92–5.24) 4.67 (4.15–5.30) 4.61 (4.08–5.37) 4.86 (4.19–5.44) 0.10 5.16 (4.57–6.16) 5.13 (4.47–5.85) 5.14 (4.48–5.90) 5.10 (4.38–5.98) 0.78
ALT (U/L) 13 (10–18) 13 (10–17) 14 (11–18) 14 (10–18) 0.48 12 (9–18) 13 (10–19) 14 (10–21) 14 (10–22) 0.05
AST (U/L) 21 (17–25) 23 (19–26) 23 (20–27) 23 (20–28)  < 0.001 20 (17–26) 21 (17–26) 21 (17–28) 23 (18–31) 0.007
eGFR (mL/min/1.73 m2) 119.54 (107.40–134.39) 119.41 (105.77–130.13) 116.88 (101.22–128.33) 108.12 (92.58–122.90)  < 0.001 113.51 (100.39–120.63) 111.67 (100.23–120.27) 108.58 (97.16–119.44) 106.71 (90.35–118.79) 0.008
Creatinine (μmol/L) 58.10 (52.33–64.85) 58.50 (53.40–64.45) 61.05 (55.43–66.83) 65.45 (57.18–72.98)  < 0.001 60.80 (55.90–65.48) 62.00 (56.90–68.05) 63.10 (58.13–69.05) 66.60 (59.85–74.68)  < 0.001
Currently smoking 19 (10.2) 36 (18.8) 20 (10.6) 43 (23.0) 0.001 15 (8.7) 20 (10.9) 29 (16.1) 50 (26.5)  < 0.001
Hypertension 96 (50.0) 119 (61.7) 122 (63.5) 141 (73.4)  < 0.001 143 (74.5) 142 (73.6) 146 (76) 152 (79.2) 0.59
Hyperlipidaemia 62 (32.2) 69 (35.8) 72 (37.0) 85 (44.3) 0.10 113 (58.9) 105 (54.4) 93 (48.4) 124 (64.6) 0.01
  1. BMI body-mass index, WHR waist hip rate, SBP systolic blood pressure, HbA1c glycated haemoglobin A1c, FPG fasting plasma glucose, 2 h PG 2 h plasma glucose concentration, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-β, homeostasis model assessment of β cell function, HDL high density lipoprotein, LDL low density lipoprotein, TG triglycerides, ALT alanine transaminase, AST aspartate aminotransferase, Egfr glomerular filtration rate