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Table 1 Characteristics of included studies for incident heart failure outcomes in patients with a reported ejection fraction ≥ 50%

From: Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis

Study

Year

Country

Design

Population

Sample Size

Mean age (years)

Sex

(% females)

% of patients with LVEF ≥ 50%

Follow-up (years)

Masoudi et al. [20]

2005

USA

Observational, retrospective cohort

T2DM, age ≥ 65 years, hospitalisation with HF

13,930

76

58

23

1.0

Romero et al. [21]

2011

Spain

Observational, prospective cohort

New-onset T2DM, HF

1519

72

54

51

4.7

Facila et al.

[19]

2017

Spain

Observational, retrospective cohort

T2DM, discharged with diagnosis of acute decompensated HF

835

72

49

49

2.4

Aguilar et al. [18]

2011

USA

Observational, retrospective cohort

T2DM, prior diagnosis of HF

6185

68

7

45a

2

  1. T2DM type 2 diabetes mellitus, HF heart failure, USA United States of America, LVEF left ventricular ejection fraction
  2. aStudy reported percentage of patients with LVEF≥ 40%