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Table 3 NMR-assessed advanced lipoprotein profile in participants without lipid-lowering drugs

From: Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

NMR variable

Controls

T1DM

p

p*

p†

(n = 317)

(n = 275)

VLDL-P number (nmol/L)

 Total

36.0 (25.3–52.4)

27.6 (21.6–36.0)

< 0.001

< 0.001

< 0.001

 Large

0.93 (0.69–1.22)

0.76 (0.60–1.03)

< 0.001

< 0.001

< 0.001

 Medium

3.88 (2.53–5.43)

2.68 (1.87–4.18)

< 0.001

< 0.001

< 0.001

 Small

31.3 (21.9–45.4)

23.8 (19.1–30.7)

< 0.001

< 0.001

< 0.001

 Ratio large/total

0.025 (0.023–0.028)

0.027 (0.025–0.030)

< 0.001

< 0.001

< 0.001

VLDL-P composition (mg/dL)

 VLDL-C

9.85 (5.37–15.76)

7.22 (4.16–11.70)

0.002

0.001

0.001

 VLDL-TG

52.0 (36.4–73.9)

38.2 (30.8–50.3)

< 0.001

< 0.001

< 0.001

 Ratio VLDL-C/VLDL-TG

0.17 (0.13–0.21)

0.19 (0.13–0.23)

0.007

0.047

0.054

VLDL-P size (nm)

42.1 (42.0–42.3)

42.1 (41.9–42.3)

0.877

0.352

0.351

LDL-P number (nmol/L)

 Total

1342.6 (1159.1–1551.7)

1276.8 (1151.7–1406.0)

< 0.001

0.001

< 0.001

 Large

191.9 (167.8–216.5)

181.7 (167.1–203.0)

0.002

0.015

0.01

 Medium

433.6 (345.2–522.9)

391.8 (331.6–471.6)

< 0.001

0.006

0.003

 Small

707.2 (618.9–815.2)

686.9 (620.7–755.0)

0.035

0.013

0.004

 Ratio small/total

0.53 (0.49–0.58)

0.54 (0.51–0.57)

0.058

0.134

0.138

LDL-P composition (mg/dL)

 LDL-C

132.5 (113.4–152.6)

126.0 (114.4–138.6)

0.004

0.014

0.006

 LDL-TG

16.2 (13.3–20.1)

14.4 (12.4–17.8)

< 0.001

< 0.001

< 0.001

 Ratio LDL-C/LDL-TG

8.30 (7.29–9.21)

8.61 (7.54–9.95)

0.003

0.006

0.007

LDL-P size (nm)

21.0 ± 0.27

21.1 ± 0.24

0.388

0.185

0.158

HDL-P number (μmol/L)

 Total

28.7 (25.7–33.02)

31.1 (27.5–35.6)

< 0.001

< 0.001

< 0.001

 Large

0.26 (0.23–0.30)

0.28 (0.25–0.31)

0.001

< 0.001

< 0.001

 Medium

9.04 (7.88–10.62)

10.43 (9.15–12.24)

< 0.001

< 0.001

< 0.001

 Small

19.7 (17.1–22.7)

20.4 (17.9–23.2)

0.079

0.018

0.012

 Ratio small/total

0.67 (0.64–0.71)

0.65 (0.62–0.68)

< 0.001

< 0.001

< 0.001

HDL-P composition (mg/dL)

 HDL-C

56.1 (49.0–65.5)

63.0 (54.6–73.8)

< 0.001

< 0.001

< 0.001

 HDL-TG

12.5 (10.1–15.6)

13.7 (11.4–16.2)

< 0.001

< 0.001

< 0.001

 Ratio HDL-C/HDL-TG

4.58 (3.63–5.59)

4.64 (3.80–5.68)

0.494

0.427

0.364

HDL-P size (nm)

8.21 ± 0.06

8.25 ± 0.07

< 0.001

< 0.001

< 0.001

Other atherogenic variables

 Non-HDL-P (nmol/L)

1369.5 (1169.6–1574.9)

1274.6 (1154.1–1406.9)

< 0.001

< 0.001

< 0.001

Ratio LDL-P/HDL-P

47.4 (38.5–58.3)

41.9 (35.5–48.5)

< 0.001

< 0.001

< 0.001

 Ratio total-P/HDL-P

45.9 (37.4–56.4)

41.1 (34.6–47.1)

< 0.001

< 0.001

< 0.001

  1. Data are shown as median (Q1–Q3) or mean ± standard deviation
  2. *p-value adjusted for age and sex
  3. †p-value adjusted for age, sex, BMI and leukocyte count
  4. HDL high-density lipoprotein, HDL-C cholesterol content in HDL, HDL-P HDL particles, HDL-TG triglyceride content in HDL, LDL low-density lipoprotein, LDL-C cholesterol content in LDL, LDL-P LDL particles, LDL-TG triglyceride content in LDL, NMR nuclear magnetic resonance, T1DM type 1 diabetes mellitus, VLDL very low-density lipoprotein, VLDL-C cholesterol content in VLDL, VLDL-P VLDL particles, VLDL-TG triglyceride content in VLDL
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Cardiovascular Diabetology

ISSN: 1475-2840