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Table 2 NMR-assessed advanced lipoprotein profile in control and T1DM groups

From: Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

NMR variable

Controls

T1DM

p

p*

p†

(n = 347)

(n = 508)

VLDL-P number (nmol/L)

 Total

36.5 (25.5–53.3)

29.1 (22.8–37.7)

< 0.001

< 0.001

< 0.001

 Large

0.93 (0.71–1.24)

0.82 (0.63–1.04)

< 0.001

< 0.001

< 0.001

 Medium

3.92 (2.62–5.50)

2.80 (1.88–4.28)

< 0.001

< 0.001

< 0.001

 Small

31.4 (22.1–47.0)

25.4 (20.1–32.5)

< 0.001

< 0.001

< 0.001

 Ratio large/total

0.025 (0.023–0.027)

0.027 (0.025–0.030)

< 0.001

< 0.001

< 0.001

VLDL-P composition (mg/dL)

 VLDL-C

9.94 (5.44–16.11)

7.78 (4.42–11.80)

0.001

< 0.001

< 0.001

 VLDL-TG

52.8 (36.5–75.3)

41.0 (32.2–53.5)

< 0.001

< 0.001

< 0.001

 Ratio VLDL-C/VLDL-TG

0.17 (0.13–0.21)

0.19 (0.13–0.23)

0.003

0.056

0.075

VLDL-P size (nm)

42.1 (42.0–42.3)

42.1 (41.9–42.3)

0.348

0.502

0.469

LDL-P number (nmol/L)

 Total

1356.2 (1159.3–1567.7)

1244.6 (1127.7–1382.6)

< 0.001

< 0.001

< 0.001

 Large

191.9 (167.6–217.6)

175.7 (159.9–195.2)

< 0.001

< 0.001

< 0.001

 Medium

437.6 (344.6–531.3)

373.4 (315.5–461.0)

< 0.001

< 0.001

< 0.001

 Small

708.6 (623.5–827.3)

684.1 (622.0–751.7)

0.001

< 0.001

< 0.001

 Ratio small/total

0.53 (0.49–0.58)

0.55 (0.51–0.59)

< 0.001

0.094

0.098

LDL-P composition (mg/dL)

 LDL-C

132.9 (113.5–154.2)

122.4 (110.1–137.0)

< 0.001

< 0.001

< 0.001

 LDL-TG

16.6 (13.4–20.4)

14.6 (12.5–17.6)

< 0.001

< 0.001

< 0.001

 Ratio LDL-C/LDL-TG

8.20 (7.25–9.13)

8.25 (7.35–9.60)

0.042

0.003

0.003

LDL-P size (nm)

21.0 ± 0.27

21.0 ± 0.27

0.35

0.163

0.142

HDL-P number (μmol/L)

 Total

29.0 (26.0–33.2)

31.8 (29.2–36.0)

< 0.001

< 0.001

< 0.001

 Large

0.26 (0.23–0.30)

0.27 (0.25–0.31)

0.002

< 0.001

< 0.001

 Medium

9.12 (7.90–10.60)

10.47 (9.19–12.11)

< 0.001

< 0.001

< 0.001

 Small

19.9 (17.4–22.8)

20.9 (18.5–23.8)

0.001

0.009

0.005

 Ratio small/total

0.67 (0.64–0.71)

0.66 (0.63–0.69)

< 0.001

< 0.001

< 0.001

HDL-P composition (mg/dL)

 HDL-C

56.2 (49.2–65.5)

63.0 (54.9–73.3)

< 0.001

< 0.001

< 0.001

 HDL-TG

12.7 (10.3–15.7)

14.7 (12.2–17.7)

< 0.001

< 0.001

< 0.001

 Ratio HDL-C/HDL-TG

4.49 (3.61–5.52)

4.32 (3.58–5.31)

0.101

0.315

0.215

HDL-P size (nm)

8.21 ± 0.06

8.25 ± 0.07

< 0.001

< 0.001

< 0.001

Other atherogenic variables

 Non-HDL-P (nmol/L)

1377.2 (1170.7–1578.5)

1239.8 (1128.6–1382.4)

< 0.001

< 0.001

< 0.001

 Ratio LDL-P/HDL-P

46.1 (37.2–56.7)

39.4 (33.3–45.5)

< 0.001

< 0.001

< 0.001

 Ratio total-P/HDL-P

47.7 (38.3–58.4)

40.4 (34.0–46.7)

< 0.001

< 0.001

< 0.001

  1. Data are shown as median (Q1–Q3) or mean ± standard deviation
  2. *p-value adjusted for age, sex, and lipid-lowering medications
  3. †p-value adjusted for age, sex, lipid-lowering medications, BMI and leukocyte count
  4. HDL high-density lipoprotein, HDL-C cholesterol content in HDL, HDL-P HDL particles, HDL-TG triglyceride content in HDL, LDL low-density lipoprotein, LDL-C cholesterol content in LDL, LDL-P LDL particles, LDL-TG triglyceride content in LDL, NMR nuclear magnetic resonance, T1DM type 1 diabetes mellitus, VLDL very low-density lipoprotein, VLDL-C cholesterol content in VLDL, VLDL-P VLDL particles, VLDL-TG triglyceride content in VLDL
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Cardiovascular Diabetology

ISSN: 1475-2840