Table 3 Relation of the GDF-15 level and MACEs in univariate and multivariate survival analysis
| Â | Independent predictors of major adverse cardiac events | |||||
|---|---|---|---|---|---|---|
Univariate models | Multivariate models | |||||
HR | 95% CI | P | HR | 95% CI | P | |
Age | 1.02 | 1.013−1.026 | 0.00 | 1.02 | 1.009−1.022 | 0.00 |
Sex | 0.00 | 0.001−0.028 | 0.00 | 0.01 | 0.001−0.057 | 0.00 |
Smoking | 1.10 | 0.933−1.296 | 0.23 | – | – | – |
BMI | 0.98 | 0.959−1.000 | 0.05 | 1.00 | 0.977−1.020 | 0.89 |
Hypertension | 1.03 | 0.646−0.880 | 0.00 | 0.82 | 0.703−0.967 | 0.02 |
Hyperlipidemia | 1.15 | 0.98–1.34 | 0.09 | – | – | – |
DM | 0.79 | 0.680–0.911 | 0.00 | 0.89 | 0.767–1.032 | 0.14 |
GDF-15 ≤ 1200 ng/L | 1.05 | 0.87–1.44 | 0.16 | – | – | – |
1200 < GDF-15 ≤ 1800 ng/L | 1.09 | 0.90–1.65 | 0.08 | – | – | – |
GDF-15 > 1800 ng/L | 1.92 | 1.37–2.52 | < 0.001 | 1.74 | 1.44–2.02 | < 0.001 |