Fig. 1

Possible issues in the management of people with diabetes and COVID-19 in ICU. Several issues are present during the management of people with diabetes and COVID-19 in ICU. Tight glycemic control, avoiding hypoglycemia and glucose variability improves the prognosis. This goal, to be achieved, needs insulin infusion and continuous glucose monitoring (CGM). *Moreover, the achievement of tight glucose control may be influenced by the background anti-hyperglycemic therapy and by the concomitant therapy with hydroxychloroquine (risk of hypoglycemia) or corticosteroids (inducing hyperglycemia). **The evaluation of the meaning of several biomarkers related to the risk of cardiovascular complications, thrombosis and inflammation must be careful, because many of them are already altered by diabetes itself. There is no contraindication, however, to the use of ACEi or ARBS to control blood pressure. ACEi angiotensin-converting-enzyme inhibitors, ARBs angiotensin-receptor-blockers, CV cardio-vascular, CGM continuous glucose monitoring, CRP C-reactive protein, Hs-Troponin High-sensitive troponin, ICU Intensive Care Unit, IL-6 interleukin-6, NT-proBNP N-Terminal-pro-Brain Natriuretic-Peptide