Models | HR (95% CI) | Concordance (95% CI) |
---|---|---|
1st part of analyses: comparative predictive ability of various HbA1c measures for MVD riska | ||
 Model with HbA1c-SD | 1.1371 (1.0596;1.2202)*** | 0.6712 (0.6546;0.6877) |
 Model with HbA1c-CV | 3.4154 (1.6495;7.0718)*** | 0.6709 (0.6544;0.6874) |
 Model with HVS | 1.0015 (0.9995;1.0035) | 0.6680 (0.6511;0.6850) |
 Model with HbA1c-meanoverall | 1.0918 (1.0359;1.1507)** | 0.6715 (0.6550;0.6879) |
 Model with HbA1c-meanyearly | 1.0797 (1.0287;1.1333)** | 0.6737 (0.6572;0.6901) |
 Model with HbA1c-meanyearly + HVS |  | 0.6727 (0.6557;0.6896) |
 HbA1c-meanyearly | 1.0830 (1.0204;1.1495)** |  |
 HVS | 1.0003 (0.9980;1.0026) |  |
 Model with HbA1c-index (as continuous variable) | 1.0649 (1.0290;1.1020)*** | 0.6741 (0.6579;0.6903) |
2nd part of analyses: comparative predictive ability of various HbA1c variability and mean measures for MVD risk, independent of baseline glycemic control [HbA1c-index, as dichotomous variable at a cut-off of 7.5% (58Â mmol/mol)]b | ||
 HbA1c-SD | 1.1153 (1.0312;1.2063)** | 0.6734 (0.6569;0.6899) |
 HbA1c-CV | 2.8119 (1.2766;6.1941)* | 0.6733 (0.6568;0.6898) |
 HVS | 1.0006 (0.9985;1.0027) | 0.6709 (0.6540;0.6878) |
 HbA1c-meanoverall | 1.0614 (0.9982;1.1287) | 0.6727 (0.6563;0.6891) |
 HbA1c-meanyearly | 1.0532 (0.9939;1.1160) | 0.6740 (0.6576;0.6905) |
 HbA1c-meanyearly + HVS |  | 0.6731 (0.6562;0.6901) |
 HbA1c-meanyearly | 1.0590 (0.9907;1.1320) |  |
 HVS | 1.0001 (0.9979;1.0024) |  |
Sensitivity analyses: comparative predictive ability of various HbA1c variability and mean measures for MVD risk, independent of baseline glycemic control [HbA1c-index, as dichotomous variable at a cut-off of 8.0% (64Â mmol/mol)]b | ||
 HbA1c-SD | 1.1089 (1.0222;1.2030)* | 0.6735 (0.6570;0.6901) |
 HbA1c-CV | 2.6340 (1.1665;5.9477)* | 0.6735 (0.6569;0.6900) |
 HVS | 1.0004 (0.9983;1.0025) | 0.6709 (0.6540;0.6878) |
 HbA1c-meanoverall | 1.0519 (0.9844;1.1194) | 0.6724 (0.6888;0.6560) |
 HbA1c-meanyearly | 1.0461 (0.9875;1.1083) | 0.6740 (0.6575;0.6905) |
 HbA1c-meanyearly + HVS |  | 0.6732 (0.6563;0.6902) |
 HbA1c-meanyearly | 1.0516 (0.9841;1.1237) |  |
 HVS | 1.0000 (0.9977;1.0023) |  |