From: The adipokine fatty-acid binding protein 4 and cardiac remodeling
All (n = 331) | Male (n = 236) | Female (n = 95) | p-value | |
---|---|---|---|---|
Baseline characteristics | ||||
Age, mean (sd) | 63.1 (12.6) | 62.4 (12.9) | 64.6 (11.8) | 0.156 |
Hypertension, n (%) | 246 (74.8) | 176 (74.9) | 70 (74.5) | 1.00 |
Diabetes, n (%) | 57 (17.4) | 47 (20.1) | 10 (10.6) | 0.06 |
Active smoking, n (%) | 59 (18.0) | 42 (17.9) | 17 (18.3) | < 0.001 |
Coronary artery disease, n (%) | 140 (42.6) | 114 (48.5) | 26 (27.7) | 0.002 |
Late gadolinium enhancement, n (%) | 129 (39.1) | 104 (44.1) | 25 (26.6) | 0.005 |
Perfusion deficit, n (%) | 65 (19.8) | 49 (20.9) | 16 (17.0) | 0.525 |
Atrial fibrillation, n (%) | 66 (20.2) | 48 (20.5) | 18 (19.6) | 0.969 |
Body mass index (kg/m2), mean (sd) | 27.5 (4.7) | 27.7 (4.3) | 27.0 (5.5) | 0.21 |
Height (cm), mean (sd) | 174.4 (9.7) | 178.4 (7.7) | 164.4 (6.3) | < 0.001 |
Weight (kg), mean (sd) | 83.7 (16.6) | 88.1 (15.2) | 72.7 (14.6) | < 0.001 |
Heart rate beats per min, mean (sd) | 68 [12] | 68 [12] | 68 [12] | 0.947 |
Cardiac magnet resonance imaging variables | ||||
LVMI (g/m2), mean (sd) | 44.5 (14.9) | 47.6 (15.0) | 36.6 (11.1) | < 0.001 |
LVEF (%), mean (sd) | 65.2 (6.5) | 64.8 (6.7) | 66.2 (5.9) | 0.087 |
LVEDD (mm), mean (sd) | 49.6 (6.5) | 51.0 (6.5) | 46.3 (5.3) | < 0.001 |
RVEDD (mm), mean (sd) | 33.8 (6.8) | 35.0 (6.5) | 30.9 (6.9) | < 0.001 |
RWT, mean (sd) | 0.30 (0.12) | 0.31 (0.13) | 0.28 (0.09) | 0.014 |
Laboratory results | ||||
NT-proBNP (ng/L), median [IQR] | 179.6 [76.9, 389.6] | 179.3 [71.9, 416.5] | 181.5 [81.1, 328.3] | 0.592 |
CRP (mg/dl), median [IQR] | 0.2 [0.1, 0.4] | 0.2 [0.1, 0.4] | 0.2 [0.1, 0.4] | 0.568 |
hs-cTnT (ng/L), median [IQR] | 9 [5, 16] | 10 [6, 17] | 8 [5, 14] | 0.007 |
Creatinin (µmol/L), mean (sd) | 88.4 (61.9) | 97.2 (70.7) | 97.2 (26.5) | < 0.001 |
eGFR (ml/min), mean (sd) | 91.6 (32.7) | 91.5 (32.0) | 92.0 (34.5) | 0.884 |
FABP4 (ng/ml), median [IQR] | 22.79 [13.84, 36.46] | 18.36 [12.24, 31.33] | 30.69 [20.96, 49.74] | 0.001 |