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Table 5 Protective effects of SGLT2i on the kidney

From: SGLT2i: beyond the glucose-lowering effect

Action

Mechanism

Direct effects

Improve glomerular hyperfiltration

Reduce renal oxygen consumption

Reduce renal inflammatory reactions

Restore the mode of cellular energy metabolism

Indirect effects

Improve blood glucose

Improve blood pressure

Decrease uric acid levels

Promote weight loss

Increase the level of glucagon

Reduce the level of insulin

Promote diuresis