Table 2 Distribution and function of various SGLTs
Protein | Major sites of expression | Function |
|---|---|---|
SGLT1 | Small intestine | Transmembrane transport of glucose and galactose through sodium-glucose cotransport proteins in the brush margin of the small intestine and proximal convoluted tubules of the kidney |
Trachea | ||
Heart | ||
Proximal tubule of the kidney (segment S3) | ||
SGLT2 | Proximal tubules of kidney (segment S1 and S2) | Cotransport of sodium and glucose in the S1 segment of the renal proximal convoluted tubule |
SGLT3 | Small intestine | Transport of sodium (not transport of glucose) |
Lungs | ||
Uterus | ||
Thyroid | ||
Testicles | ||
SGLT4 | Small intestine | Transport of glucose and mannose |
Kidneys | ||
Liver | ||
Lungs | ||
Stomach | ||
SGLT5 | Renal cortex | Unknown |
SGLT6 | Spinal cord | Transport of inositol and glucose |
Brain | ||
Small intestine | ||
Kidney |