Table 1 Brief introduction to the features of SGLT2i

Target organ

Proximal tubule of kidney

Favorable aspects

①Lower blood glucose

②Lower blood pressure (reduce systolic BP by 2.46 mmHg and diastolic BP by 1.46 mmHg)

③Lower body weight (3 kg–4 kg reduction)

④Lower glycosylated hemoglobin (0.7%–1% reduction)

⑤Increase high-density lipoprotein (HDL) cholesterol, and decrease triglycerides.

⑥Reduce albuminuria

⑦Reduce uric acid (10%–15% reduction)

⑧Increase hematocrit (2–4% increase)

Unfavorable aspects

①Urinary tract infection

②Genital fungal infection

③Ketoacidosis

④Fracture

⑤Malignant tumor

⑥Hypotension

⑦Dehydration

⑧Hypoglycemia

⑨Lower limb amputation